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OALib Journal期刊
ISSN: 2333-9721
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羰基钌一氧化碳释放分子的毒理、组织分布及其与血液内源性物质的相互作用
, PP. 1677-1687
Keywords: 一氧化碳释放分子,毒理,组织分布,相互作用
Abstract:
co是人体内类似于no的信使分子,过渡金属羰基配合物是co的固化形式。大量研究表明羰基钌一氧化碳释放分子(corms)具有很强的药理活性,本文合成了5个羰基钌corms,从毒理、组织分布及与血液内源性物质的相互作用等方面进行了研究。研究主要包含以下方面:①通过细胞生长抑制实验获得它们对成纤维细胞的ic50介于212.9～2089.2μmol·l-1;利用小鼠测得它们的经口ld50介于800～1600mg·kg-1;血液生化分析及透射电镜检查表明多次给药后corms1及corms5对wistar大鼠肝、肾功能无显著影响,但对肝肾组织细胞造成损伤。②小鼠腹腔给药后,以icp-aes检测corms组织分布,结果表明羰基钌corms在体内主要分布于血液、肝、肾,在心、脾、肺中分布较少,不能通过血脑屏障进入脑组织;corms结构中的非co配体对化合物的吸收分布有较大影响。③corms可使牛血清白蛋白的荧光增强,其强度与corms的加入量呈正比关系;corms与gsh的反应产物随条件不同而呈现二羰基钌或三羰基钌配合物两种形态。
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