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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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抗肿瘤药物的表观遗传学研究进展
, PP. 1629-1636
Keywords: 抗肿瘤药物,表观遗传,dna甲基化,mirna,组蛋白修饰
Abstract:
表观遗传学异常不仅与某些癌症发病相关,还可能通过修饰药物吸收、分布、代谢、排泄等药动学相关基因及信号通路、作用靶点等药效学相关基因,而影响抗癌药物疗效和预后。通过调控表观调控因子发挥抗癌效应的药物正成为研究的热点。本文从dna甲基化、mirna和组蛋白修饰对抗肿瘤药物的治疗作用进行综述和分析,旨在为抗肿瘤药物安全有效的合理使用及发展"表观药物"提供新的思路。
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