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OALib Journal期刊
ISSN: 2333-9721
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低氧应激因子phd2与血管新生相关疾病
, PP. 151-157
Keywords: 低氧应激,phd2,血管新生治疗,肿瘤血管新生
Abstract:
phds家族是低氧应激的重要调控因子，通过调控低氧诱导因子hifs的稳定性和活性，使细胞和组织适应低氧应激环境。其中，phd2作为phds家族中的重要一员，是低氧诱导因子hif-1的关键调控因子。近年研究表明，phd2不仅在缺血性疾病的血管新生中起重要作用，还能通过调控肿瘤生长、转移等相关基因的表达，影响肿瘤微环境下肿瘤的生长及转移。本文就phd2的分子调控机制及其在生理病理过程中的作用机制进行综述，重点介绍phd2在血管再生治疗和肿瘤血管新生中的作用，以及目前phd2作为治疗靶标的开发应用研究。
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