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OALib Journal期刊
ISSN: 2333-9721
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静脉注射丹酚酸a在恒河猴体内的药代动力学研究
, PP. 1142-1147
Keywords: 丹酚酸a,丹酚酸b,丹酚酸c,恒河猴,药代动力学
Abstract:
丹酚酸a(salvianolicacida,sala)是从丹参根中分离得到的具有多种药理活性的化合物。本文建立的恒河猴血浆中丹酚酸a的lc-ms测定方法可用于研究丹酚酸a在恒河猴体内的药代动力学特性,并考察了同时测定猴血浆中丹酚酸a、b和c的可行性。恒河猴静脉注射丹酚酸a2.5、5和10mg·kg-1后,2min时的血药浓度(c2min)分别为(28.343±6.426)、(45.679±12.301)和(113.293±24.360)mg·l-1。药时曲线下面积(auc0-∞)分别为(3.316±0.871)、(5.754±2.150)和(13.761±2.825)μg·l-1·h。本研究为丹酚酸a的临床前及临床研究提供了数据支持,也为丹酚酸a、b和c在猴或人体内的测定提供了参考。
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