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OALib Journal期刊
ISSN: 2333-9721
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一株海绵共生真菌zsds1-f11次生代谢产物的研究
Keywords: 棕色扁海绵,海洋真菌,次生代谢产物,抗炎活性
Abstract:
？对分离自西沙棕色扁海绵phakelliafuscathiele的共附生真菌zsds1-f11的次生代谢产物进行了研究;运用硅胶柱层析、sephadexlh-20凝胶柱层析以及半制备高效液相等方法对菌株zsds1-f11的发酵产物进行分离纯化;通过理化性质及波谱学方法及参阅文献进行化学结构鉴定;采用环氧合酶-1和环氧合酶-2(cyclooxygenase,cox-1,cox-2)为分子靶标进行炎症抑制剂筛选。结果从菌株zsds1-f11的发酵产物中分离得到8个单体化合物。其中化合物1和2具有较弱的环氧合酶-1(cyclooxygenase,cox-1)抑制活性,ic50分别为27.2和2.93μmol。菌株zsds1-f11能够产生结构多样性的活性次生代谢产物,并首次报道了化合物1和2具有较弱的抗炎活性。
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