Background: Many studies
have shown that CFRD has a negative impact on CF prognosis. Current guidelines
advise to screen for CFRD with an OGTT yearly from the age of 10 - 12. In ourcenterwe do not routinely screen for CFRD
because the OGTT is cumbersome and not an ideal screening test. We therefore
want to exclude unfavourable clinical evolution due to late diagnosis. Methods:
23 CF patients with diagnosis of CFRD < 18 years old were matched to a
control patient. Clinical evolution (BMI, lung function, and chronic infection
treatment burden) was analyzed starting 2 years before until 2 years after
diagnosis of CFRD. Results: In the 2 years before diagnosis of CFRD, BMI and LF
were similar for both groups while need for IV AB treatment was higher in the
CFRD group. In the 2 years following diagnosis and treatment, LF decline was
worse in the CFRD despite more IV AB treatments. BMI was still comparable. We
conclude that clinical status was comparable between cases and controls in the
2 years preceding the diagnosis of CFRD. However, the need for IV antibiotic
treatment seems to precede the faster lung function decline after CFRD
diagnosis.
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