Matsuda N, Hattori Y. Vascular biology in sepsis: pathophysiologi- cal and therapeutic significance of vascular dysfunction[J]. J Smooth Muscle Res, 2007, 43(4): 117-137. [2] Jun CD, Shimaoka M, Carman CV, et al . Dimerization and the ef- fectiveness of ICAM-1 in mediating LFA-1-dependent adhesion[J]. Proc Natl Acad Sci USA, 2001, 98(12): 6830-6835. [3]袁利华,刘承武,姚琦,等.内毒素休克小鼠肝脏血管内皮细胞 特异性结合肽的体内筛选及初步鉴定[J].中国病理生理学杂志, 2008, 35(11): 1341-1345. [4] Levy MM, Dellinger RP, Townsend SR, et al . The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis[J]. Intensive Care Med, 2010, 36(2): 222-231. [5] Aird WC. Endothelium in health and disease[J]. Pharmacol Rep, 2008, 60(1): 139-143. [6] Dauphinee SM, Karsan A. Lipopolysaccharide signaling in endothelial cells[J]. Lab Invest, 2006, 86(1): 9-22. [7] Pasqualini R, Ruoslahti E. Organ targeting in vivo using phage dis- play peptide libraries[J]. Nature, 1996, 380(6572): 364-366. [8] Laakkonen P, Zhang L, Ruoslahti E. Peptide targeting of tumor lymph vessels[J]. Ann N Y Acad Sci, 2008, 1131: 37-43. [9] Mueller J, Gaertner FC, Blechert B, et al . Targeting of tumor blood vessels: a phage-displayed tumor-homing peptide specifically binds to matrix metalloproteinase-2-processed collagen IV and blocks angio- genesis in vivo[J]. Mol Cancer Res, 2009, 7(7): 1078-1085. [10] Du B, Han H, Wang Z, et al . targeted drug delivery to hepatocarci- noma in vivo by phage-displayed specific binding peptide[J]. Mol Cancer Res, 2010, 8(2): 135-144.