Kharitonenkov A. FGFs and metabolism[J]. Curr Opin Pharmacol, 2009, 9(6)：805-810.
[2]
Nicholes K, Guillet S, Tomlinson E, et al. A mouse model of hepatocellular carcinoma ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice[J]. Am J Pathol, 2002, 160(6)：2295-2307 .
Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice[J]. Diabetes, 2009, 58(1)：250-259.
[5]
Wang H, Xiao Y, Fu L, et al. High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli[J]. BMC Biotechnololy, 2010, 10：14.
[6]
Seo JA, Kim NH. Fibroblast growth factor 21：a novel metabolic regulator[J]. Diabetes Metab, 2012, 36：26-28.
[7]
Zhang X, Yeung DC, Karpisek M, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans[J]. Diabetes, 2008, 57：1246-1253.
[8]
Chen C, Cheung BM, Tso AW, et al. High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes：A 5. 4-year population-based prospective study in Chinese subjects[J]. Diabetes Care, 2011, 34(9)：2113-2115.
[9]
Nishimura T, Nakatake Y, Konishi M, et al. Identification of a novel FGF, FGF-21, preferentially expressed in the liver[J]. Biochim Biophys Acta, 2000, 1492(1)：203-206.
[10]
Wang H, Qiang L, Farmer SR, et al. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes[J]. Mol Cell Biol, 2008, 28(1)：188-200.
Mashili FL, Austin RL, et al. Direct effects of FGF21 on glucose upt-ake in human skeletal muscle：implications for type 2 diabetes and obesity[J]. Diabetes Metab Res Rev, 2011, 27(3)：286-297.
[16]
Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor 21[J]. Endocrinology, 2007, 148(2)：774-781.
[17]
Chen WW, Li L, et al. Circulating FGF-21 levels in normal subjects and in newly diagnosed patients with Type 2 diabetes mellitus[J]. Exp Clin Endocrinol Diabetes, 2008, 116：65-68.
Yasuhiro I, Holly AB, Noriyuki O, et al. FGF21 is an Akt-regulated myokine[J]. FEBS Letters, 2008, 58(2)：3805-3810.
[20]
Wente W, Alexander M, Efanov, et al. Fibroblast growth factor-21 improves pancreatic β-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and akt signaling Path-ways[J]. American Diabetes Association, 2006, 55(9)：2470-2478.
