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一株抗多重耐药菌海洋放线菌的筛选及其活性分析

, PP. 119-124

Keywords: 海洋放线菌,抑菌活性,链霉菌属,抗耐药菌

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Abstract:

旨在从71株海洋放线菌中筛选活性较好的抗多重耐药菌菌株。采用平板打孔抑菌法筛选对多重耐药菌的抑制作用;通过菌株形态学特征、生理生化特征和16SrDNA序列对菌株进行分类鉴定。结果显示,筛选到一株对多株多重耐药菌均有较强抑制作用的海洋放线菌MQ-86,菌株MQ-86的M2+培养基粗提物对普通的大肠杆菌(Escherichiacoli)8739、金黄色葡萄球菌(Staphylococcusaureus)6538、白色念珠菌(Candidaalbicans)10231和共耐18种主要抗生素的多重耐药性大肠杆菌(Escherichiacoli)480、大肠杆菌(Escherichiacoli)460、金黄色葡萄球菌(Staphylococcusaureus)206都有较好的抑制效果。菌株MQ-86对多株多重耐药菌均具有较强的抑制活性,经初步鉴定为小链霉菌(Streptomycesparvus)。

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