Ronau JA, Paul LN, Fuchs JE, et al. An additional substrate binding site in a bacterial phenylalanine hydroxylase[J]. Eur Biophys J, 2013, 42（9）：691-708.
[2]
Erlandsen H, Kim JY, Patch MG, et al. Structural comparison of bcterial and human iron-dependent phenylalanine hydroxylases：similar fold, different stability and reaction rates[J]. J Mol Bio, 2002, 320（3）：645-661.
Loaiza A, Armstrong KM, Baker BM, et al. Kinetics of thermal unfolding of phenylalanine hydroxylase variants containing different metal cofactors（FeII, CoII, and ZnII）and their isokinetic relationship[J]. Inorg Chem, 2008, 47（11）：4877-4883.
[6]
Chen D, Frey PA. Phenylalanine hydroxylase from Chromobac-terium violaceum uncoupled oxidation of tetrahydropterin and the role of iron in hyroxylation[J]. J Biol Chem, 1998, 273（40）：25594-25601.
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding[J]. Anal Biochem, 1976, 72（3）：248-254.
[9]
Pember SO, Benkovic SJ, Villafranca JJ, et al. Adduct formation between the cupric site of phenylalanine hydroxylase from Chromob-acterium violaceum and 6, 7-Dimethyltetrahydropterin[J]. Bioche-mistry, 1987, 26（14）：4477-4483.
[10]
Nakata H, Yamauchi T, Fujisawa H. Phenylalanine hydroxylase from Chromobacterium violaceum purification and characterization[J]. J Biol Chem, 1979, 254（6）：1829-1833.
[11]
Pember SO, Villafranca JJ, Benkovic SJ. Phenylalanine hydroxylase from Chromobacterium violaceum is a copper-containing monooxy-genase. kinetics of the reductive activation of the enzyme[J]. Biochemistry, 1986, 25（21）：6611-6619.
[12]
Onishi A, Liotta LJ, Benkovic SJ. Cloning and expression of Chro-mobacterium violaceurn phenylalanine hydroxylase in Escherichia coli and comparison of amino acid sequence with mammalian aromatic amino acid hydroxylas[J]. J Biol Chem, 1991, 266（28）：18454-18459.
[13]
Koehntop KD, Emerson JP, Que L Jr. The 2-his-1-carboxylate facial triad：a versatile platform for dioxygen activation by mononuclear non-heme iron（II）enzymes[J]. J Biol Inorg Chem, 2005, 10（2）：87-93.
[14]
Yew NS, Dufour E, Przybylska M, et al. Erythrocytes encapsulated with phenylalanine hydroxylase exhibit improved pharmacokinetics and lowered plasma phenylalanine levels in normal mice[J]. Mol Genet Metab, 2013, 109（4）：339-344.
