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腺苷酸活化蛋白激酶在哺乳动物卵巢发育中的调控作用及其机制

DOI: 10.3969/j.issn.1006-267x.2015.10.003

Keywords: AMPK,卵巢,葡萄糖,IGF-1,FSH,脂联素

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Abstract:

腺苷酸活化蛋白激酶(AMPK)信号通路作为调节细胞能量代谢状态的中心环节,是调控哺乳动物繁殖性能的关键因子。已有研究表明,AMPK在哺乳动物卵巢发育中主要通过介导葡萄糖、胰岛素样生长因子-1(IGF-1)、促卵泡素(FSH)、脂联素等发挥功能。本文就AMPK在哺乳动物卵巢发育中的调控作用及其机制进行综述,旨在引起人们对AMPK调控卵巢发育的关注,并为卵巢疾病的治疗提供一定参考。

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