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饥饿激素与能量代谢

DOI: 10.3969/j.issn.1006-267x.2015.08.006

Keywords: 能量代谢,ghrelin,酰基化,分子机制

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Abstract:

饥饿激素(ghrelin)是生长激素促分泌素受体的唯一内源性配体,也是唯一可以在外周刺激食欲的激素。ghrelin在机体食欲、体重、胃肠功能、脂肪代谢、葡萄糖代谢及脂类代谢等生理活动的调节中发挥着重要作用。ghrelin的酰基化是与其受体结合产生相应生物学效应的前提。本文系统综述了ghrelin在能量代谢中的作用模式与分子机制。

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