FRANK J W, ESCOBAR J, NGUYEN H V, et al. Oral N-carbamylglutamate (NCG) supplementation increases growth rate in sow-reared piglets[J]. Journal of the Federation of American Societies for Experimental Biology, 2006, 20:A425.
[2]
WU G, BAZER F W, CUDD T A, et al. Maternal nutrition and fetal development[J]. The Journal of Nutrition, 2004, 134:2169-2172.
[3]
GAO H, SPENCER T E, WU G, et al. mTOR signaling mechanisms in the ovine uterus[J]. Biology Reproduction, 2006, 124:568-574.
[4]
WU G, FANG Y Z, YANG S, et al. Glutathione metabolism and its implications for health[J]. The Journal of Nutrition, 2004, 134:489-492.
[5]
MATEO R D, WU G, CARROLL J A, et al. Dietary L-arginine supplementation improves pregnancy outcome in gilts[J]. Journal of Animal Science, 2006, 84 (Suppl. 2):7-8.
[6]
NEWSHOLME P, BRENNNAN L, RUBI B, et al. New insights into amino acid metabolism, beta-cell function and diabetes[J]. Clinical Science, 2005, 108:185-194.
[7]
FLYNN N E, MEININGER C J, HAYNES T E, et al. The metabolic basis of arginine nutrition and pharmacotherapy[J]. Biochemical Pharmacology, 2002, 56:427-438.
[8]
ZHOU R Y, PENG J, LIU Z L, et al. Effects of biocom as a replacement of glutamine on performance and blood biochemical indexes of early weaned piglets[J]. Asian-Australasian Journal of Animal Sciences, 2006, 19:872-876.
[9]
HA E M, OH C T, BAE Y S, et al. A direct role for dual oxidase in Drosophila gut immunity[J]. Science, 2005, 310:847-850.
[10]
WU G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs[J]. American Journal Physiology, 1997, 272:G1382-1390.
[11]
D’MELLO J P F. Amino acids in animal nutrition[M]// KIM S W, EASTER R A. Amino acid utilization for reproduction in sows. Wallingford: CABI Publishing, 2003:203-222.
[12]
POND W G, BELL A W. Encyclopedia of animal science[M]// WU G, SELF J T. Amino acids: metabolism and functions. New York: Marcel Dekker, Inc., 2005:9-12.
[13]
KWON H, SPENCER T E, BAZER F W, et al. Developmental changes of amino acids in ovine fetal fluids[J]. Biology Reproduction, 2003, 68:1813-1820.
[14]
FLYNN N E, KNABE D A, MALLICK B K, et al. Postnatal changes of plasma amino acids in suckling pigs[J]. Journal of Animal Science, 2000, 78:2369-2375.
[15]
MELCHIOR D, LE F N, SEVE B. Effect of chronic lung inflammation on tryptophan metabolism in piglets[J]. Advance Express Medicine and Biology, 2003, 527:359-362.
[16]
WU G, KNABE D A. Free and protein-bound amino acids in sow’s colostrums and milk[J]. The Journal of Nutrition, 1994, 124:415-424.
[17]
FLYNN N E, WU G. An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs[J]. American Journal of Physiology, 1996, 271:R1149-R1155.
[18]
WU G, THOMPSON J R. The effect of glutamine on protein turnover in chick skeletal muscle in vitro[J]. Biochemical Journal, 1990, 265:593-598.
[19]
WU G, BAZER F W, TUO W, et al . Unusual abundance of arginine and ornithine in porcine allantoic fluid[J]. Biology of Reproduction, 1996, 54:1261-1265.
[20]
BAKER D H. Ideal amino acid profiles for swine and poultry and their applications in feed formulation[J]. Biokyowa Technical Review, 1997, 9:1-24.
[21]
TISCHLER M E, DESAUTELS M, GOKDBERG A L. Does leucine, leucyl-transfer RNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?[J] Journal of Biological Chemistry, 1982, 257:1613-1621.
[22]
ESCOBAR J, FRANK J W, SURYAWAN A, et al. Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation[J]. American Journal Physiology, 2005, 288:E914-E921.
[23]
ESCOBAR J, FRANK J W, SURYAWAN A, et al. Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs[J]. American Journal Physiology, 2006, 290:E612-E621.
[24]
MEIJER A J, DUBBELHUIS P F. Amino acid signaling and the integration of metabolism[J]. Biochemical and Biophysical Research Communications, 2004, 313:397-403.
[25]
BAN H, SHIGEMITSU K, YAMATSUJI T, et al. Arginine and leucine regulate p70S6 kinase and 4E-BP1 in intestinal epithelial cells[J]. International Journal of Molecular Medicine, 2004, 13:537-543.
[26]
CURTHOYS N P, WATFORD M. Regulation of glutaminase activity and glutamine metabolism[J]. Annual Review of Nutrition, 1995, 15:133-159.
[27]
MACLENNAN P A, BROWN R A, RENNIE M J. A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle[J]. Federation of European Biochemical Societies Letters, 1987, 215:187-191.
COEFFIER M, CLAEYSSENS S, HECKETSWEILER B, et al. Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa[J]. American Journal of Physiology, 2003, 285:G266-G273.
[31]
XIA Y, WEN H Y, YOUNG M E, et al. Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine[J]. Journal of Biological Chemistry, 2003, 278:13143-13150.
[32]
FUMAROLA C, MONICA S L, GUIDOTTI G G. Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: role of glutamine and of cell shrinkage[J]. Journal of Cell Physiology, 2005, 204:155-165.
[33]
WU G, MEIER S A, KNABE D A. Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs[J]. The Journal of Nutrition, 1996, 126:2578-2584.
[34]
TROTTIER N L, SHIPLEY C F, EASTER R A. Plasma amino acid uptake by the mammary gland of the lactating sow[J]. Journal of Animal Science, 1997, 75:1266-1278.
[35]
SELF J T, SPENCER T E, JOHNSON G A, et al. Glutamine synthesis in the developing porcine placenta[J]. Biology Reproduction, 2004, 70:1444-1451.
[36]
CORI B A, RHOADS M, HARRELL R J, et al. Rotaviral enteritis stimulates ribosomal p70 s6 kinase and increases intestinal protein synthesis in neonatal pigs[J]. Journal of the Federation of American Societies for Experimental Biology, 2005, 19:A976.
[37]
WU G, MORRIS S M, Jr. Arginine metabolism: nitric oxide and beyond[J]. Biochemistry Journal, 1998, 336:1-17.
[38]
WU G, KNABE D A, FLYNN N E, et al. Arginine degradation in developing porcine enterocytes[J]. American Journal Physiology, 1996, 271:G913-G919.
[39]
WU G, JAEGER L A, BAZER F W, et al. Arginine deficiency in premature infants: biochemical mechanisms and nutritional implications[J]. Jounal Nutrition Biochemistry, 2004, 15:442-451.
[40]
KIM S W, MCPHERSON R L, WU G. Dietary arginine supplementation enhances the growth of milk-fed young pigs[J]. The Journal of Nutrition, 2004, 134:625-630.
[41]
WU G, BAZER F W, HU J, et al. Polyamine synthesis from proline in the developing porcine placenta[J]. Biology Reproduction, 2005, 72:842-850.
[42]
MARTIN P M, SUTHERLAND A E, VAN WINKLE L J. Amino acid transport regulates blastocyst implantation[J]. Biology Reproduction, 2003, 69:1101-1108.
[43]
BROSNAN J T. Amino acids, then and now-a reflection on Sir Hans Kreb’s contribution to nitrogen metabolism[J]. Journal of the International Union of Biochemistry and Molecular Biology, 2001, 52:265-270.
[44]
SHI W, MEININGER C J, HAYNES T E, et al. Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells[J]. Cell Biochemistry and Biophysics, 2004, 41:415-433.
[45]
WU G, MEININGER C J. Regulation of nitric oxide synthesis by dietary factors[J]. Annual Review of Nutrition, 2002, 22:61-86.
[46]
FU W, HAYNES T E, KOHLI R, et al. Dietary supplementation with L-arginine reduces fat mass in Zucker diabetic fatty rats[J]. The Journal of Nutrition, 2005, 135:714-721.
[47]
JOBGEN W S, FRIED S K, FU W J, et al. Regulatory role for the arginine-nitric oxide pathway in energy-substrate metabolism[J]. Jounal Nutrition Biochemistry, 2010, 17:571-588.
[48]
STEAD L M, BROSNAN J T, BROSNAN M E, et al. Is it time to reevaluate methyl balance in humans?[J] American Journal of Clinical Nutrition, 2006, 83:5-10.
[49]
WU G, FLYNN N E, FLYNN S P, et al. Dietary protein or arginine deficiency impairs constitutive and inducible nitric oxide synthesis by young rats[J]. The Journal of Nutrition, 1999, 129:1347-1354.
[50]
WU G, KNABE D A, KIM S W. Arginine nutrition in neonatal pigs[J]. The Journal of Nutrition, 2004, 134:S2783-S2790.
[51]
FIELD C J, JOHNSON I R, SCHLEY P D. Nutrients and their role in host resistance to infection[J]. Journal of Leukocyte Biology, 2002, 71:16-32.
[52]
WU G, FIELD C J, MARLISS E B. Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytes[J]. American Journal of Physiology, 1991, 260:E141-E147.
[53]
PARRYBILLINGS M, EVANS J, CALDER P C, et al. Does glutamine contribute to immunosuppression after major burns?[J] Lancet, 1990, 336:523-525.
[54]
GRIMBLE R. F. Modification of inflammatory aspects of immune function by nutrients[J]. Nutrition Research, 1998, 18:1297-1317.
[55]
BRONTE V, ZANOVELLO P. Regulation of immune responses by L-arginine metabolism[J]. Nature Review Immunology, 2005, 5:641-654.
[56]
KIM S W, MCPHERSON R L, WU G. Dietary arginine supplementation enhances the immune status of milk-fed young pigs[J]. Journal of the Federation of American Societies for Experimental Biology, 2004, 18:A378.
[57]
KIM S W, MATEO R D, WU G, et al. Dietary L-arginine supplementation affects immune status of pregnant gilts[J]. Journal of the Federation of American Societies for Experimental Biology, 2006, 1:A266.
[58]
ESTEBAN S, NICOLAUS C, GARMUNDI A, et al. Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat[J]. Molecular Cell Biochemistry, 2004, 267:39-46.
[59]
PLATTEN M, HO P P, YOUSSEF S, et al. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite[J]. Science, 2005, 310:850-855.
