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microRNA在骨骼肌发育中的功能及其表达的营养调控

DOI: 10.3969/j.issn.1006-267x.2011.10.001

Keywords: microRNA,骨骼肌发育,营养调控

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Abstract:

microRNA(miRNA)是真核生物中一类参与调控基因表达的非编码小分子RNA,它通过翻译抑制和使靶mRNA降解,在基因表达中起着负调控作用,与骨骼肌发育、疾病等密切相关。营养可以调控miRNA及其靶基因的表达,这将为更深层次诠释营养素的作用机理提供新的研究方向。本文综述了miRNA的结构和作用机制、骨骼肌miRNA在不同动物中的表达谱、miRNA对骨骼肌发育的调控、miRNA与骨骼肌疾病的关系和miRNA表达的营养调控的研究进展。

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