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宫内发育迟缓对胰腺内分泌功能影响的研究进展

DOI: 10.3969/j.issn.1006-267x.2011.10.003

Keywords: 宫内发育迟缓,胰腺,内分泌功能

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Abstract:

宫内发育迟缓(IUGR)是围产期胎儿死亡的主要原因之一,是动物新生期及后期代谢性疾病发生的重要原因,且在多胎动物中常有发生。目前试验较常用的IUGR建模方法有:子宫动脉结扎法、限制母体能量法和限制母体蛋白质法。随着IUGR动物模型的广泛应用,许多学者发现IUGR阻碍胰腺β细胞的发育、分化及增殖,表现为β细胞数量减少,胰腺中胰岛素含量降低,胰岛素分泌受损,进而引发代谢性疾病。本文综述了IUGR对胰腺内分泌功能的影响。

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