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维生素D生物学效价研究的一些新进展

DOI: 10.3969/j.issn.1006-267x.2012.11.002

Keywords: 维生素D,生物学效价,评定方法,影响因素

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Abstract:

关于维生素D生物学效价的评定方法主要分为生物学方法和化学方法,然而至今对其没有统一的结论。研究结果大部分显示维生素D3的效价高于或等于维生素D2的效价,且维生素D3及其代谢产物效价的对比大致为维生素D3≤24,25-二羟基维生素D3[24,25-(OH)2D3]=25,26-二羟基维生素D3[25,26-(OH)2D3]≤25-羟基维生素D3[25-(OH)D3]≤1,25-二羟基维生素D3[1,25-(OH)2D3]。影响维生素D生物学效价的因素有多种,其内在因素主要包括关键酶的活性及其反馈调节机制、活性维生素D的结构与维生素D转运蛋白及维生素D受体的亲和性差异等;外在因素主要有试验动物、评价指标及评价方法、光照、维生素D载体等。本文主要从维生素D生物学效价的评定方法、内在和外在的影响因素方面进行综述,为相关研究提供一定的参考依据。

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