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整联蛋白及其信号转导途径对骨骼肌生长发育的调控

DOI: 10.3969/j.issn.1006-267x.2012.07.003

Keywords: 整联蛋白,信号转导,骨骼肌生长发育

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Abstract:

整联蛋白广泛存在于真核细胞的细胞膜表面,是一类α、β异源二聚体膜受体蛋白,可使细胞黏附于胞外基质并介导来自基质的机械信号和化学信号,并通过细胞膜的双向信号转导作用来调节细胞分化、迁移、免疫、黏附等生物学功能。本文总结了整联蛋白信号途径的功能特点和活化特点,重点阐述了整联蛋白及其介导的信号转导途径对骨骼肌生长发育的调控。

References

[1]  LUO B H,CARMAN C V,SPRINGER T A.Structural basis of integrin regulation and signaling[J].Annual Review Immunology,2007,25(6):619-647.
[2]  O''REILLYA M,LEE H H,SIMON M A.Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary[J].Journal of Cell Biology,2008,182:801-815.
[3]  DINKINS M B,FRATTO V M,LEMOSY E K.Integrin α chain exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary[J].Developmental Dynamics,2008,237:3927-3939.
[4]  ETHERIDGE T,OCZYPOK E A,LEHMANN S,et al.Calpains mediate integrin attachment complex maintenance of adoult muscle in Caenorhabditis elegans[J].PLoS Gentics,2012,1(8):1-20.
[5]  SEJEONG S,LAURA W,SANG-OH Y.Integrin trafficking and tumor progression[J].International Journal of Cell Biology,2012,2012:1-7.
[6]  HU J,ZHAO H F,LIU J,et al.Integrin β1 subunit from Ostrinia furnacalis hemocytes:molecular characterization,express,and effects on the spreading of plasmatocytes[J].Journal of Insect Physiology,2010,56:1846-1856.
[7]  BHARADWAJ S,VASABTH G,MASUELLI L,et al.Inhibition of nuclear accumulation of phosphorylated ERK by tropomyosin-1-mediated cytoskeletal reorganization[J].Cancer Molecular,2008,4(5):139-144.
[8]  MOSER M,BAUER M,SCHMID S,et al.Kindlin-2 is required for myocyte elongation and is essential for myogensis[J].BioMed Central Cell Biology,2008,9:36.
[9]  TAVORA B,BATISTA S,REYNOLDS L E,et al.Endothelial FAK is required for tumour angiogenesis[J].European Molecular Biology Organization Molecular Medicine,2010,2(12):516-528.
[10]  PARK Y M,FEBBRAIO M,SILVERSTEIN R L.CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima[J].Journal of Clinical Investigation,2009,119(1):136-145.
[11]  SHI Z D,WANG H,JOHN M,et al.Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen[J].PloS One,2011,6(1):1-10.
[12]  HUANG C Y,FU X L,LIU J,et al.The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers[J].Biomaterials,2012,33:1791-1800.
[13]  张勇,孙璀.钙调磷酸酶-活化T细胞核因子信号途径在骨骼肌细胞生长和发育中生理作用的研究进展[J].动物营养学报,2011,23(4):536-541.
[14]  张勇,邓科.骨骼肌特异性蛋白酶与蛋白质降解[J].动物营养学报,2011,23(4):542-545.
[15]  SPARROW J C,SCHOCK F.The initial steps of myofibril assembly:integrins pave the way[J].Nature Reviews Molecular Cell Biology,2009,10:293-298.
[16]  VERTEGAAL A O.Uncovering ubiquitin and ubiquitin-like signaling networks[J].American Chemical Society,2011,111(12):7923-7940.
[17]  HARSTON R K,KUPPUSWAMY D.Integrins are the necessary links to hypertrophic growth in cardiomyocytes[J].Journal of Signal Transduction,2011,10:1-8.
[18]  MENON B,SINGH M,ROSS R S,et al.β-adrenergic receptor-stimulated apoptosis in adult cardiacmyocytes involves MMP-2-mediated disruption of β integrin signaling and mitochondrial pathway[J].American Journal of Physiology,2006,290(1):254-261.
[19]  PERKINS A D,STEPHANIE J,SHAMSIAN P A I,et al.Integrin-mediated adhesion maintains sarcomeric integrity[J].Developmental Biology,2010,338:15-27.
[20]  GAWLIK K I,DURBEEJ M.Skeletal muscle laminin and MDC1A:pathogenesis and treatment strategies[J].Skeletal Muscle,2011(1):2-13.

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