全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

牛磺酸对脂多糖诱导的小鼠肝脏损伤的缓解作用

DOI: 10.3969/j.issn.1006-267x.2015.03.040

Keywords: 牛磺酸,肝脏损伤,氧化应激,脂多糖,小鼠

Full-Text   Cite this paper   Add to My Lib

Abstract:

本试验旨在研究牛磺酸对脂多糖(LPS)诱导的小鼠肝脏损伤的缓解作用。选用30只体重(22±3)g的ICR雄性小鼠,随机分为3组(每组10只小鼠,n=10):对照组和LPS组饲喂基础饲粮,牛磺酸组在基础饲粮中添加2.5%的牛磺酸。饲喂1周后LPS组和牛磺酸组小鼠腹腔注射10mg/kg的LPS(LPS溶解于生理盐水,注射剂量为0.2mL/只),对照组小鼠腹腔注射等体积的生理盐水。LPS注射24h后,各组小鼠眼眶采血并处死,采集肝脏。血液用于血清谷丙转氨酶(ALT)和谷草转氨酶(AST)活性的测定,肝脏称重后检测氧化应激参数,抗氧化基因及转录因子E2相关因子2(Nrf2)、Kelch样ECH相关蛋白(Keap1)的相对表达量。结果表明:1)LPS处理显著升高了小鼠的肝脏指数(P<0.05),而添加牛磺酸显著抑制了由LPS引起的肝脏指数升高(P<0.05)。2)LPS处理显著增加了血清ALT和AST活性(P<0.05),添加牛磺酸后抑制了血清ALT和AST活性的增加,且其AST活性达到对照组水平(P>0.05)。3)LPS组小鼠肝脏出现明显的损伤,而牛磺酸组小鼠肝脏组织损伤较轻。4)与对照组相比,LPS组小鼠肝脏丙二醛(MDA)含量显著上升(P<0.05),谷胱甘肽过氧化物酶(GPx)活性显著降低(P<0.05),而牛磺酸组上述指标未发生显著变化(P>0.05)。5)牛磺酸显著缓解了LPS对肝脏GPx1和Nrf2表达的抑制作用(P<0.05)。综上所述,饲粮中添加2.5%的牛磺酸对LPS诱导的小鼠肝脏损伤起到了一定的缓解作用。

References

[1]  RIPPS H,SHEN W.Review:taurine:a "very essential" amino acid[J].Molecular Vision,2012,18:2673-2686.
[2]  MAIA A R,BATISTA T M,VICTORIO J A,et al.Taurine supplementation reduces blood pressure and prevents endothelial dysfunction and oxidative stress in post-weaning protein-restricted rats[J].PLoS One,2014,9(8):e105851.
[3]  GURUNG R B,PURBE B,GYAWALI P,et al.The ratio of aspartate aminotransferase to alanine aminotransferase (AST/ALT):the correlation of value with underlying severity of alcoholic liver disease[J].Kathmandu University Medical Journal,2013,11(43):233-236.
[4]  DEMINICE R,ROSA F T,DA SILVA L E C M,et al.Taurine supplementation does not decrease homocysteine levels and liver injury induced by a choline-deficient diet[J].Life Sciences,2014,105(1/2):43-47.
[5]  LIU Y T,YANG L Q,TAO K M,et al.Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release[J].BMC Gastroenterology,2014,14(1):12.
[6]  ZHANG Z Y, LIU D,YI B,et al.Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model[J].Molecular Medicine Reports,2014,10(5):2255-2262.
[7]  GIUDICE A,ARRA C,TURCO M C.Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents[J].Methods in Molecular Biology,2010,647:37-74.
[8]  AGCA C A,TUZCU M,HAYIRLI A,et al.Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats[J].Food and Chemical Toxicology,2014,71:116-121.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133