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维生素D通过Wnt信号通路对肠道发育调控机制的研究进展

DOI: 10.3969/j.issn.1006-267x.2015.03.006

Keywords: Wnt信号通路,肠道发育,维生素D受体

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Abstract:

Wnt信号通路广泛存在于脊椎和无脊椎动物体内,对动物机体各组织器官发育,如肝脏、肾脏、肠道等起着至关重要的作用。维生素D是一组脂溶性类固醇衍生物,维生素D不直接作用于靶器官,而是通过与维生素D受体(VDR)结合从而发挥其生物学效应。近年来研究表明,VDR可以通过影响Wnt信号通路的传导进而影响肠道发育,本文就VDR对Wnt信号通路的影响、Wnt信号通路对肠道发育的调控机制等方面作一综述,以期为Wnt信号通路在肠道发育调控研究提供参考。

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