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维生素A调节动物一氧化氮的生成及其相关机制

DOI: 10.3969/j.issn.1006-267x.2015.03.003

Keywords: 维生素A,硫氧还蛋白还原酶,白细胞介素,一氧化氮

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Abstract:

动物机体由于旺盛的新陈代谢或在受到外界有害因素刺激的情况下会产生大量一氧化氮(NO),进而损伤细胞中的蛋白质、类脂膜和DNA,引发细胞炎症并阻断细胞信号通路,使机体产生氧化应激。维生素A可以有效地调控NO的生成,提高机体抗氧化水平并清除自由基,预防细胞炎症及氧化应激的发生。本文主要综述了维生素A对动物NO生成的调节作用及其相关机理的研究进展,对今后深入研究其调节机理、科学补充维生素A及提高机体的抗氧化功能具有一定参考价值。

References

[1]  张浩,昝金行,刘培勋.诱导型一氧化氮合酶抑制剂的研究进展[J].中国新药杂志,2013,22(6):665-669.
[2]  HALLEMEESCH M M,JANSSEN B J A,DE JONGE W J,et al.NO production by cNOS and iNOS reflects blood pressure changes in LPS-challenged mice [J].American Journal Physiology,2003,285(4):E871-E875.
[3]  MONCADA S,HIGGS E A.The discovery of nitric oxide and its role in vascular biology[J].British Journal of Pharmacology,2006,147(S1):S193-S201.
[4]  U?AR-?ANKAL D,OZMERIC N.A multifaceted molecule,nitric oxide in oral and periodontal diseases[J].Clinica Chimica Acta,2006,366(1/2):90-100.
[5]  SCHMIDT H H H W,WALTER U.NO at work[J].Cell,1994,78(6):919-925.
[6]  柳晨.基于TRX转基因细胞抗氧化应激损伤作用中对NO水平的调节作用研究[D].硕士学位论文.大连:大连医科大学,2013.
[7]  SHINDE U A,MEHTA A A,GOYAL R K.Nitric oxide:a molecule of the millennium[J].Indian Journal of Experimental Biology,2000,38(3):201-210.
[8]  BOGDAN C,R?LLINGHOFF M,DIEFENBACH A.Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity[J].Current Opinion in Immunology,2000,12(1):64-76.
[9]  BANAN A,FIELDS J Z,DECKER H,et al.Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction[J].The Journal of Pharmacology and Experimental Therapeutics,2000,294(3):997-1008.
[10]  潘会君,唐宁,华晓东,等.中药调控一氧化氮合酶-一氧化氮系统的研究[J].中国实验方剂学杂志,2010,16(12):201-205.
[11]  FERRET P J,SOUM E,NEGRE O,et al.Protective effect of thioredoxin upon NO-mediated cell injury in THP1 monocytic human cells[J].The Biochemical Journal,2000,346(Pt 3):759-765.
[12]  MILLER L A,USACHENKO J,MCDONALD R J,et al.Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin-and pertussis toxin-sensitive signaling mechanisms[J].Journal of Leukocyte Biology,2000,68(2):201-208.
[13]  JIN L,YAN S M,SHI B L,et al.Effects of vitamin A on the milk performance,antioxidant functions and immune functions of dairy cows[J].Animal Feed Science and Technology,2014,192:15-23.
[14]  CHU F F,ESWORTHY R S,LEE L,et al.Retinoic acid induces Gpx2 gene expression in MCF-7 human breast cancer cells[J].The Journal of Nutrition,1999,129(10):1846-1854.
[15]  景志忠,窦永喜,罗启慧,等.猪白介素家族重要基因的克隆、表达及其结构与功能预测分析[J].中国农业科学,2006,39(3):612-619.
[16]  田学忠,刘越,陈华,等.白细胞介素1和诱导型一氧化氮合酶在兔肢体缺血再灌注后关节软骨中的表达[J].中国组织工程研究与临床康复,2007,11(45):9021-9025.
[17]  顾蓓蓓.视黄醇对脂多糖诱导的大鼠乳腺炎症反应的调节及机制研究[D].博士学位论文.南京:南京农业大学,2010.
[18]  BEYAERT R,CUENDA A,BERGHE W V,et al.The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor[J].The EMBO Journal,1996,15(8):1914-1923.
[19]  CHEN C C,WANG J K.p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages[J].Molecular Pharmacology,1999,55(3):481-488.
[20]  沈亚伟.全反式维甲酸对肺气肿大鼠氧化应激的影响研究[D].硕士学位论文.合肥:安徽医科大学,2011.
[21]  YOO M H,CARLSON B A,GLADYSHEV V N,et al.Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus[J].PLoS ONE,2013,8(9):e71427.

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