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氨基酸感知与代谢调控的研究进展

DOI: 10.3969/j.issn.1006-267x.2015.02.003

Keywords: 氨基酸感知,氨基酸应答,雷帕霉素靶蛋白,代谢

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Abstract:

氨基酸不仅是蛋白质和其他含氮化合物合成的重要前体,还参与体内主要代谢途径的调控.当氨基酸不足时,机体内多种机制参与调节体内平衡,包括快速停止蛋白质合成、增加氨基酸合成和转运,以及加强自噬作用.越来越多的学者证明氨基酸可作为信号分子参与细胞内信号传导过程,可以调节其他营养素如脂肪和能量的代谢,最终导致机体整体代谢的改变.本文主要综述细胞内氨基酸的营养感知与应答机制,涉及氨基酸应答(AAR)和雷帕霉素靶蛋白(TOR)2条信号转导通路,并探讨这2条信号通路对下游营养素代谢途径的调节.

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