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亚急性瘤胃酸中毒对奶山羊血浆细胞因子和激素含量的影响

DOI: 10.3969/j.issn.1006-267x.2015.02.012

Keywords: 亚急性瘤胃酸中毒,奶山羊,细胞因子,激素

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Abstract:

本试验旨在研究以递增饲粮非纤维性碳水化合物与中性洗涤纤维比(NFC/NDF)方式诱导奶山羊发生亚急性瘤胃酸中毒(SARA)后,血浆细胞因子和激素含量的变化.选取9只体况良好,体重接近的泌乳期莎能奶山羊,随机分为3组(对照组、SARA组、恢复组,n=3),对照组饲喂基础饲粮,SARA组和恢复组先后饲喂NFC/NDF为1.40、1.79、2.31、3.23的4种试验饲粮诱导SARA发生,每种饲喂15d,恢复组奶山羊诱导SARA后自由采食青干草30d.对照组3只羊分别在饲养30、60(与SARA组同时)和90d(与恢复组同时)屠宰.结果表明:1)SARA长期提高了血浆LPS浓度,恢复组与SARA组差异不显著(P>0.05).2)与对照组相比,SARA组奶山羊血浆中促炎性细胞因子肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β和IL-6含量呈升高趋势(P>0.05),IL-2含量显著升高(P<0.05),IL-8含量呈降低趋势(P>0.05),γ-干扰素(IFN-γ)含量显著降低(P<0.05),抗炎性细胞因子IL-4和IL-10含量均呈降低趋势(P>0.05);SARA组奶山羊血浆中生长激素、胰岛素样生长因子-Ⅰ、胰岛素含量变化不显著(P>0.05),催乳素(PRL)和皮质醇(COR)含量均显著升高(P<0.05).3)与SARA组相比,恢复组奶山羊血浆中TNF-α、IL-1β、IL-2、IL-6这些促炎性细胞因子的含量仍持续性升高,其中IL-1β和IL-2含量显著升高(P<0.05);恢复组奶山羊血浆中PRL含量仍维持与SARA组同一水平(P>0.05),而COR含量则回归到对照组水平(P>0.05).本研究结果显示,SARA可引起奶山羊血浆中长时间含有一定量的LPS,引发机体免疫和炎症反应,并引起内分泌激素的变化,这一系列变化导致奶山羊长期处于应激状态.

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