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营养素对畜禽炎症表观遗传学的调控及其机制

DOI: 10.3969/j.issn.1006-267x.2015.02.008

Keywords: 营养素,炎症,DNA甲基化,组蛋白修饰,抗炎

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Abstract:

炎症是动物机体对病原菌、损伤组织和刺激物等产生的有害刺激做出的一种生理性应答.炎症反应可通过调节多种炎症介质及信号通路最终影响炎症因子的表达.表观遗传学涉及非DNA序列改变引起的可遗传变化,主要包括DNA甲基化、组蛋白修饰和非编码RNA表达调控.表观遗传修饰可通过影响炎症反应中相关基因的表达来调节炎症反应,饲粮中能够影响表观遗传学修饰过程的营养素可调节炎症反应.本文主要综述了营养素调控炎症的表观遗传学机制--DNA甲基化和组蛋白修饰.

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