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瞬时受体电位2通道介导动物氧化应激的机理及其营养调控

DOI: 10.3969/j.issn.1006-267x.2013.10.006

Keywords: 瞬时受体电位2,氧化应激,营养物质

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Abstract:

瞬时受体电位2(TRPM2)是一种具有离子通道和二磷酸腺苷核糖水解酶双重功能的蛋白质,能被二磷酸腺苷核糖和活性氧自由基激活。当细胞膜Ca2+通透性增大时,TRPM2通道可作为氧化还原的感受器介导氧化应激,并激活Ca2+产生依赖性的细胞反应,如血管内皮的渗透压增加和细胞的凋亡。本文就TRPM2通道特征、氧化应激激活TRPM2通道的机理和营养物质通过TRPM2通道缓解氧化应激的机理进行了综述。

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