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畜产动物过氧化物酶体增殖物激活受体基因的表达模式及功能研究进展

DOI: 10.3969/j.issn.1006-267x.2013.05.006

Keywords: 过氧化物酶体增殖物激活受体,表达模式,功能,畜产动物

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Abstract:

过氧化物酶体增殖物激活受体(PPARs)是一类配体依赖的核转录因子,属核受体超家族成员。自从PPARs于1990年被发现以来,研究人员对啮齿动物和人体PPARs基因的结构与多态性、组织中表达模式、影响表达的因素、信号传导途径以及调控脂类代谢等方面的功能进行了广泛和深入的研究。近年来,PPARs基因在畜禽及鱼类中的表达模式及功能的研究也逐渐开展起来,并取得了一些进展。本文对PPARs基因在畜产动物组织中的表达模式及功能研究进行了综述。

 References

[1]  ISSEMANN I,GREEN S.Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators[J].Nature,1990,347:645-650.
[2]  SAMPHTH H,NTAMBI J M.Polyunsaturated fatty acid regulation of genes of lipid metabolism[J].Annual Review of Nutrition,2005,25:317-340.
[3]  BRAISSANT O,WAHLI W.Differential expression of peroxisome proliferatoractivated receptor-alpha,-beta,and -gamma during rat embryonic development [J].Endocrinology,1998,139:2748-2754.
[4]  QINGLIN Y,YUHAO L.Roles of PPARs on regulating myocardial energy and lipid homeostasis[J].International Journal of Molecular Medicine,2007,85:697-706.
[5]  RICOTE M,LI A C,WILSON T M,et al.The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation[J].Nature,1998,391:79-82.
[6]  JIANG C,TING A T,SEED B.PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines[J].Nature,1998,391:82-86.
[7]  DESVERGNE B,WHALI W.Peroxisome proliferator activated receptors:nuclear control of metabolism[J].Endocrinology Review,1999,20:649-688.
[8]  李龙江,余瑜.脂代谢的信号转导途径[J].儿科药学杂志,2005,11(1):7-9.
[9]  BRAISSANT O,FOUFELLE F,SCOTTO C,et al.Differential expression of peroxisome proliferator-activated receptors (PPARs):tissue distribution of PPAR-alpha,-beta,and -gamma in the adult rat[J].Endocrinology,1996,137:354-366.
[10]  ELBRECHT A,CHEN Y,CULLINAN C A,et al.Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2[J].Biochemical and Biophysical Research Communicatons,1996,224:431-437.
[11]  ERIC B,JEANO C G,RURH R.Advances in understanding the regulation of apoptosis and mitosis by peroxisome proliferator-activated receptors in preclinical models relevance for human health and disease[J/OL].Comparative Hepatological,2003(2):1-8.[2003-01-31].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151270/.
[12]  叶卫雄,严瑾.PPARs配体的研究进展[J].浙江中医药大学学报,2009,33(4):606-610.
[13]  JPENBERG A,JEANNIN E,WAHLI W,et al.Polarity and specific sequence requirements of peroxisome proliferator activated receptors (PPAR)/retinoid X receptor heterodimer binding to DNA:a functional analysis of malic enzyme gene PPAR response element[J].Journal of Biological Chemistry,1997,137:272-281.
[14]  SUNDVOLD H,GRINDFLEK E,LIEN S.Tissue distribution of porcine peroxisome proliferator activated receptor α:detection of an alternatively spliced mRNA[J].Gene,2001,273:105-113.
[15]  赵玉琼,姚春涛,刘亚千,等.我国特有三个小型猪品系PPARα基因的多态性分析[J].中国比较医学杂志,2008,18(10):41-44.
[16]  GRINDFLEK E,SUNDVOLD H,LIEN S,et al.Rapid communication:physical and genetic mapping of the peroxisome proliferator receptor gamma (PPAR gamma) gene to porcine chromosome 13 [J].Journal of Animal Science,2000,78(5):1391-1392.
[17]  王博,吴江维,杨公社.PPARγ在八眉猪不同组织中的表达差异[J].畜牧兽医学报,2008,39(3):273-277.
[18]  GRINDFLEK E,SUNDVOLD H,KLUNGLAND H,et al.Characterization of porcine peroxisome proliferator-activated receptor C1 and C2:detection of breed and age difference in gene expression [J].Biochemical and Biophysical Research Communications,1998,249:713-718.
[19]  龚兰,金邦荃,章熙霞,等.杂交山猪骨骼肌PPARγ、RARα基因与脂代谢关系的研究[J].食品科学,2011,32:62-67.
[20]  刘海峰,阎振鑫,董涵,等.猪前脂肪细胞诱导分化过程中PPARγ、DECR1和ECHS1基因表达模式[J].四川农业大学学报,2010,28(2):215-218.
[21]  陈哲,王公金,于建宁,等.PPARγ2基因外显子1多态性对猪胴体性状的影响[J].江苏农业学报,2012,28(2):332-336.
[22]  REBECCA E,STEVEN M,KEITH I,et al.An investigation into the genetic controls of pork quality[J].National Swine Improvement Federation,2000,77:846-852.
[23]  KONG L J,WANG A G,FU J L,et al.Peroxisome proliferator-activated receptor c is involved in weaning to estrus of primiparous sows by regulating the expression of hormone genes in hypothalamus-pituitary-ovary axis[J].Asian and Australian Journal of Animal,2007,20(3):340-350.
[24]  GUIYING W,LUJIN K,PENG H,et al.Effect of polymorphism in the peroxisome proliferator-activated receptor gamma gene on litter size of pigs[J].Molecular Biology Reports,2011,38:1807-1812.
[25]  KONG L J,WANG A G,FU J L,et al.Study on the characteristics of tissue expression of peroxisome proliferators-activated receptors in pigs[J].Chinese Journal of Animal Science,2006,42(19):1-4.
[26]  李京励,孔路军,王爱国,等.猪PPARs基因在胚胎附植期子宫内膜表达特性研究[J].中国畜牧杂志,2012,48(11):15-17.
[27]  马云,王云云,张晓婷,等.鸭PPARα基因结构及功能的生物信息学分析[J].浙江大学学报:农业与生命科学版,2011,37(4):371-379.
[28]  孟和,李辉,王宇祥.鹅PPARα基因全长cDNA的克隆和序列分析[J].遗传,2004,26(4):469-472.
[29]  孟和,李辉,王宇祥.鸡PPARs基因组织表达特性的研究[J].遗传学报,2004,31(7):682-687.
[30]  林婄婄,高中元,袁亚男,等.PPARα和PPARγ基因在不同脂尾型绵羊脂肪组织中的发育性表达研究[J].畜牧兽医学报,2012,43(9):1368-1376.
[31]  郝称莉,李齐发,乔永,等.湖羊肌肉组织H-FABP和PPARγ基因表达水平与肌内脂肪含量的相关研究[J].中国农业科学,2008,41(11):3776-3783.
[32]  HUANG Z G,XIONG L,LIU Z S,et al.The developmental changes and effect on IMF content of H-FABP and PPARγ mRNA expression in sheep muscle[J].Acta Genetica Sinica,2006,33:507-514.
[33]  李健.西杂牛PPARγ2、PGC-1a、MEF2C基因表达量及其与肌内脂肪含量、嫩度的相关分析[D].硕士学位论文.雅安:四川农业大学,2010.
[34]  樊月圆,富国文,昝林森.过氧化物酶体增殖激活受体α(PPARα)基因突变对牛的背膘厚和胴体长的影响[J].家畜生态学报,2012,33(1):14-18.
[35]  樊月圆,昝林森,王洪宝,等.牛过氧化物酶体增殖激活受体α(PPARα)基因第5外显子多态性与胴体、肉质性状的相关性[J].农业生物技术学报,2010,18(4):713-718.
[36]  方文良,黄金明,王长法,等.中国荷斯坦牛PPARα基因多态性研究及其与耐热性能的关联分析[J].中国畜牧兽医,2010(8):165-170.
[37]  HYUN K C,HEE J K,HVE Y K,et al.Characterization of paralichthys olivaceus peroxisome proliferator-activated receptor-a gene as a master regulator of flounder lipid metabolism[J].General and Comparative Endocrinology,2012,175:39-47.
[38]  HYUN K C,HEE J K,BO H N,et al.Molecular cloning and characterization of olive flounder (Paralichthys olivaceus) peroxisome proliferator-activated receptor γ[J].General and Comparative Endocrinology,2009,163:251-258.
[39]  林亚秋,吉红,郑玉才.草鱼PPARα和PPARγ基因的克隆与组织表达差异[J].水产学报,2011,30(2):94-97.
[40]  陈亮,梁旭方,瞿春梅,等.草鱼过氧化物酶体增殖物激活受体(PPARs)基因cDNA序列的克隆及其组成型表达[J].暨南大学学报:自然科学版,2011,32(1):80-87.
[41]  钱伦,钱云霞,童丽娟.大黄鱼PPARβ全长cDNA的克隆和组织表达[J].生物学杂志,2010,27(6):1-4.
[42]  贾成霞,张照斌,张清靖.虹鳟PPARα基因克隆、序列分析及其组织表达分布[J].中国水产科学,2012,19(4):707-714.
[43]  CARLA B P,PEDRO R,EDUARDO R,et al.Identification and organ expression of peroxisome proliferator activated receptors in brown trout (Salmo trutta f.fario)[J].Biochimica et Biophysica Acta,2005,1731:88-94.
[44]  钱云霞,杨孙孝,梁洪,等.鲈PPARγ基因的克隆、组织表达及其抗体制备[J].水产学报,2010,34(8):1156-1164.
[45]  TSAI M L,CHEN H Y,TSENG M C,et al.Cloning of peroxisome proliferators activated receptors in the cobia (Rachycentron canadum) and their expression at different life-cycle stages under cage aquaculture[J].Gene,2008,425(12):69-78.
[46]  ANDERSEN Q,EIJSINK V G,THOMASSEN M.Multiple variants of the peroxisome proliferator-activated receptor (PPAR) γ are expressed in the liver of Atlantic salmon(Salmosalar) [J].Gene,2000,255:411-418.
[47]  DAMIEN R,IBON C,MIREN P,et al.Cloning and expression pattern of peroxisome proliferator-activated receptor a in the thicklip grey mullet Chelon labrosus[J].Marine Environmental Research,2006,62:113-S117.
[48]  IBABE A,GRABENBAUER M,BAUMGART E,et al.Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio)[J].Histochemistry of Cell Biology,2002,118:231-239.
[49]  DESVERGNE B,JJPENBERG A,DEVEHAND P R,et al.The peroxisome proliferators-activated receptors at the cross-road of diet and hormonal signaling[J].Journal of Steroid Biochemistry and Molecular Biology,1998,65(1):65-74.
[50]  RUYTER B O,ANDERSEN A K,FARRANTS T,et al.Peroxisome proliferator activated receptors in Atlantic salmon (Salmo salar):effects on PPAR transcription and acyl-CoA oxidase activity in hepatocytes by peroxisome proliferators and fatty acids[J].Biochimica et Biophysica Acta,1997,1348:331-338.
[51]  DU Z Y,DEMIZIEUX P,DEGRACE J,et al.Alteration of 20∶5n-3 and 22∶6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout[J].Lipids,2004,39:849-855.
[52]  MOYA-FALCON C E,HYATTUM T N,TRAN M S,et al.Phospholipid molecular species,beta-oxidation,desaturation and elongation of fatty acids in Atlantic salmon hepatocytes:effects of temperature and 3-thia fatty acids[J].Comparative Biochemistry and Physiology B:Biochemistry & Molecular Biology,2006,145:68-80.
[53]  JI H,LI J,LIU P.Regulation of growth performance and lipid metabolism by dietary n-3 highly unsaturated fatty acids in juvenile grass carp,Ctenopharyngodon idellus[J].Comparative Biochemistry and Physiology,2011,159:49-56.
[54]  赵占宇.共轭亚油酸(CLA)对大黄鱼脂肪代谢、免疫、肉品质及PPAR基因表达的影响[D].博士学位论文.杭州:浙江大学,2008.
[55]  LEAVER M J,TOCHER A,OBACH L,et al.Effect of dietary conjugated linoleic acid (CLA) on lipid composition,metabolism,and gene expression in Atlantic salmon (Salmo salar) tissues[J].Comparative Biochemistry and Physiology A:Molecular & Integrative Physiology,2006,145:258-267.
[56]  DIZ A D,MENOYO S,PEREZ-BENAVENTE J,et al.Conjugated linoleic acid affects lipid composition,metabolism,and gene expression in gilthead sea bream (Sparus aurata L)[J].The Journal of Nutrition,2007,137:1363-1369.
[57]  DIOT C,DUAIRE M.Characterization of a cDNA sequence encoding the peroxisome proliferat or-activated receptor α in the chicken[J].Poultry Science,1999,78:1198-1202.
[58]  田亚东,亢娟娟,孙桂荣,等.PPARα基因对安卡×固始鸡资源群胴体品质的遗传效应分析[J].华北农学报,2010,25(6):14-18.
[59]  孟和,王桂华,王启贵,等.鸡PPARα基因单核苷酸多态与脂肪性状相关的研究[J].遗传学报,2002,29(2):119-123.
[60]  王丽,那威,王宇祥,等.鸡PPARγ基因的表达特性及其对脂肪细胞增殖分化的影响[J].遗传,2012,34(5):454-464.
[61]  苏胜彦,李齐发,刘振山,等.朗德鹅填饲后不同组织PPARγ基因mRNA表达量差异的初步研究[J].畜牧兽医学报,2008,39(7):879-884.

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