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早期生长反应因子-1生物学特性及功能

DOI: 10.3969/j.issn.1006-267x.2013.04.003

Keywords: 早期生长反应因子-1,生物学特性,生长发育,生殖,机体免疫

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Abstract:

早期生长反应因子-1(Egr-1)具有调节细胞生长和分化的作用,通过调控细胞周期中一系列与细胞生长增殖分化有关的基因表达而参与细胞生长调控过程,进而促进细胞增生和组织修复。Egr-1受多种上游分子的调控并结合到下游分子启动子区域的特定序列,当受到多种刺激因子作用后可快速诱导和表达并通过其下游分子发挥不同的功能。本文就Egr-1对动物生长、生殖和机体免疫的影响进行了综述。

References

[1]  SWATI B,MINGHUA W,FENG F,et al.Early growth response transcription factors:key mediators of fibrosis and novel targets for anti-fibrotic therapy[J].Matrix Biology,2011(30):235-242.
[2]  董克,吕杰强,朱雪琼.转录因子Egr-1及其在女性生殖系统中的作用[J].中国妇幼健康研究,2007,18(4):333-336.
[3]  DANUTA S,BERND G,CHRISTINA S,et al.Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells[J].Nephrol Dial Transplant,2009,24(1):52-61.
[4]  李新蔚,张勇.整联蛋白及其信号转导途径对骨骼肌生长发育的调控[J].动物营养学报,2012,24(7):1201-1206.
[5]  张勇,马勇,朱宇旌,等.p38丝裂原活化蛋白激酶信号途径调节骨骼肌生长发育的机理[J].动物营养学报,2012,24(1):14-19.
[6]  李崇辉,刘巨超,臧传波,等.巨噬细胞内毒素耐受时TLR4/MD-2的基因表达调节作用[J].中华实验外科杂志,2004,21(1):28-30.
[7]  CRON R Q,BANDYOPADHYAY R,GENIN A,et al.Early growth response-1 is required for CD154 transsciption[J].The Journal of Immunology,2006,176(2):811-818.
[8]  张勇,李欣蔚,朱宇旌,等.细胞外信号调节激酶信号途径及其与动物肌肉生长发育的关系[J].动物营养学报,2012,24(2):191-197.
[9]  BAE M H,JEONQ C H,KIM S H,et al.Regulation of Egr-1 by association with the proteasome component C8[J].Biochimica et Biophysica Acta,2002,1592(2):163-167.
[10]  张勇,崔岩.NF-κB在细胞凋亡中的调节作用和应用前景[J].动物营养学报,2011,23(5):715-719.
[11]  YU J,BARON V,MERCOLA D,et al.A network of p73,p53 and Egr1 is required for efficient apoptosis in tumor cells[J].Cell Death Differ,2007(14):436-446.
[12]  KOSTADINOVA R M,NAWROCKI A R,FREY F J,et al.Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1[J].The FASEB Journal,2005,19(6):650-652.
[13]  LEVKOVITZ Y,BARABAN J M.A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation:role of an Egr/c-Jun complex[J].The Journal of Neuroscience,2002,22 (10):3845-3854.
[14]  TORGERSEN K M,AANDAHL E M,TASKEN K.Molecular architecture of signal complexes regulating immune cell function[J].Handbook of Experimental Pharmacology,2008,186(3):327-363.

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