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胰岛素对促性腺激素释放激素分泌及活性的调控

DOI: 10.3969/j.issn.1006-267x.2013.01.001

Keywords: 胰岛素,促性腺激素释放激素,早期生长应答蛋白-1,胞外信号调节激酶,神经肽Y

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Abstract:

胰岛素是动物体内能量代谢调控的重要激素,促性腺激素释放激素(GnRH)是动物体内调控繁殖的重要激素,是使动物发情的起始因素。促进家畜尽早进入发情期是现今畜牧业中的一个重要课题。大量研究报道了通过控制动物体内胰岛素水平可影响GnRH水平,从而调控动物发情。本文综述了胰岛素调节GnRH活性和功能过程中早期生长应答蛋白-1、胞外信号调节激酶和神经肽Y发挥的作用,对养殖生产实践中通过胰岛素调控实现GnRH分泌释放的机理作简要的总结。

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