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猪的肠道微生物与宿主营养代谢

DOI: 10.3969/j.issn.1006-267x.2014.10.016

Keywords: 肠道微生物,微生物-肠道-大脑轴,宿主-微生物代谢轴,蛋白质,碳水化合物,机体整体代谢

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Abstract:

肠道中栖息着数量庞大复杂多样的微生物菌群,肠道微生物在宿主健康中发挥着重要作用,既影响着饲料消化、营养物质吸收和能量供应,又调控着宿主正常生理功能及疾病的发生与发展。动物胃肠道不仅是消化器官,还是感应器官,肠道对营养物质的感应可以通过脑肠轴调节机体生理活动。肠道微生物还能代谢蛋白质产生宿主细胞不能合成的肽类物质,并通过小肠上皮的肽类转运系统影响机体代谢,因此可能存在微生物-肠道-大脑轴。肠道微生物还可以与机体形成宿主-微生物代谢轴,对动物机体营养物质代谢和免疫稳态起重要作用。饲粮对宿主代谢的改变,常伴随有肠道微生物区系的变化,肠道微生物的代谢可能通过微生物-肠道-大脑轴以及宿主-微生物代谢轴调节宿主很多生理过程,进而影响机体整体代谢。本文概述了猪肠道微生物区系与宿主肠道营养物质代谢的关系,以加深关于肠道微生物对机体代谢贡献的认识。

References

[1]  ADIBI S A.The oligopeptide transporter (Pept-1) in human intestine:biology and function[J].Gastroenterology,1997,113(1):332-340.
[2]  STOLL B,HENRY J,REEDS P J,et al.Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets[J].The Journal of Nutrition,1998,128(3):606-614.
[3]  CHEN L X,YIN Y L,JOBGEN W S,et al.In vitro oxidation of essential amino acids by jejunal mucosal cells of growing pigs[J].Livestock Science,2007,109(1/2/3):19-23.
[4]  YANG Y X,DAI Z L,ZHU W Y.Important impacts of intestinal bacteria on utilization of dietary amino acids in pigs[J].Amino Acids,2014,doi:10.1007/s00726-014-1807-y.
[5]  JHA R,LETERME P.Feed ingredients differing in fermentable fibre and indigestible protein content affect fermentation metabolites and faecal nitrogen excretion in growing pigs[J].Animal,2011,6(4):603.
[6]  DAI Z L,WU G Y,ZHU W Y.Amino acid metabolism in intestinal bacteria:links between gut ecology and host health[J].Frontiers in Bioscience,2011,16:1768-1786.
[7]  MATSUMOTO M,KIBE R,OOGA T,et al.Impact of intestinal microbiota on intestinal luminal metabolome[J].Scientific Reports,2012,2:233.
[8]  ICHIMURA A,HIRASAWA A,HARA T,et al.Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis[J].Prostaglandins & Other Lipid Mediat,2009,89(3/4):82-88.
[9]  KIMURA I,OZAWA K,INOUE D,et al.The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43[J].Nature Communications,2013,4:1829.
[10]  PUIMAN P,STOLL B,MOLBAK L,et al.Modulation of the gut microbiota with antibiotic treatment suppresses whole body urea production in neonatal pigs[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2013,304(3):G300-G310.

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