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含能材料  2011 

一种简易合成3,5-二氨基吡啶的方法

DOI: 10.3969/j.issn.1006-9941.2011.05.007

Keywords: 有机化学,3,5-二甲基吡啶,3,5-二氨基吡啶,霍夫曼降解,3,5-二甲氧羰基氨基吡啶

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Abstract:

研究了一种简易合成3,5-二氨基吡啶及其氨基被保护的衍生物的方法,以3,5-二甲基吡啶为原料,经高锰酸钾氧化、酰胺化和霍夫曼降解简便的三步反应合成了3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶,总收率分别在70%和72%以上。讨论了各步反应主要的影响因素,并用1HNMR、MS/MS、IR、元素分析等方法对中间体和产物的结构进行了表征。

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