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一种新型T1-T2双模磁共振造影剂的制备及性能研究

, PP. 102-109

Keywords: Fe3O4@SiO2@Gd2O(CO3)2核/壳/壳纳米粒子,双模磁共振造影剂,生物相容性

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Abstract:

研究了Fe3O4@SiO2@Gd2O(CO3)2核/壳/壳磁性纳米粒子,作为一种新型的T1-T2双模磁共振成像造影剂.并对这种纳米粒子的细胞活性进行了体外细胞毒性试验(MTT).结果显示其具有良好的生物相容性,有望成为一种新型双模磁共振造影剂.

References

[1]  PETORAL JR R M, SDERLIND F, KLASSON A, et al. Synthesis and characterization of Tb3+-doped Gd2O3 nanocrystals: a bifunctional material with combined fluorescent labeling and MRI contrast agent properties[J]. The Journal of Physical Chemistry C, 2009, 113(17): 6913-6920.
[2]  王鑫,刘飞,李明泽,刘欣,等. 多模式成像技术概述以及研究进展[J]. 国际生物医学工程杂志, 2010, 33(2):99-105.
[3]  DE LEN-RODRGUEZ L M, LUBAG A, UDUGAMASOORIYA D G, et al. MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid-(Gd) 8-Dendron for Targeting[J]. Journal of the American Chemical Society, 2010, 132(37): 12829-12831.
[4]  NA H B, SONG I C, HYEON T. Inorganic nanoparticles for MRI contrast agents[J]. Advanced Materials, 2009, 21(21): 2133-2148.
[5]  LOUIS C, BAZZI R, MARQUETTE C A, et al. Nanosized hybrid particles with double luminescence for biological labeling[J]. Chemistry of Materials, 2005, 17(7): 1673-1682.
[6]  JUN Y, LEE J H, CHEON J. Chemical Design of Nanoparticle Probes for High-Performance Magnetic Resonance Imaging[J]. Angewandte Chemie International Edition, 2008, 47(28): 5122-5135.
[7]  CARAVAN P. Strategies for increasing the sensitivity of gadolinium based MRI contrast agents[J]. Chemical Society Reviews, 2006, 35(6): 512-523.
[8]  KIELAR F, TEI L, TERRENO E, et al. Large relaxivity enhancement of paramagnetic lipid nanoparticles by restricting the local motions of the GdIII chelates[J]. Journal of the American Chemical Society, 2010, 132(23): 7836-7837.
[9]  DAS G K, HENG B C, NG S C, et al. Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging[J]. Langmuir, 2010, 26(11): 8959-8965.
[10]  ARBAB A S, LIU W, FRANK J A. Cellular magnetic resonance imaging: current status and future prospects[J]. Expert Review of Medical Devices, 2006, 3(4): 427-439.
[11]  CHOI J, LEE J H, SHIN T H, et al. Self-confirming “AND” logic nanoparticles for fault-free MRI[J]. Journal of the American Chemical Society, 2010, 132(32): 11015-11017.
[12]  PARK J, AN K, HWANG Y, et al. Ultra-large-scale syntheses of monodisperse nanocrystals[J]. Nature Materials, 2004, 3(12): 891-895.
[13]  YI D K, LEE S S, Papaefthymiou G C, et al. Nanoparticle architectures templated by SiO2/Fe2O3 nanocomposites[J]. Chemistry of Materials, 2006, 18(3): 614-619.
[14]  LIU G, HONG G, SUN D. Synthesis and characterization of SiO 2Gd 2O3: Eu core-shell luminescent materials[J]. Journal of Colloid and Interface Science, 2004, 278(1): 133-138.
[15]  RIFE J C, MILLER M M, SHEEHAN P E, et al. Design and performance of GMR sensors for the detection of magnetic microbeads in biosensors[J]. Sensors and Actuators A: Physical, 2003, 107(3): 209-218.
[16]  JIANG W, WU Y, HE B, et al. Effect of sodium oleate as a buffer on the synthesis of superparamagnetic magnetite colloids[J]. Journal of Colloid and Interface Science, 2010, 347(1): 1-7.
[17]  WANG L, NAGESHA D K, SELVARASAH S, et al. Toxicity of CdSe nanoparticles in Caco-2 cell cultures[J]. J Nanobiotechnology, 2008, 6(11):1-15.
[18]  TSAI Z T, TSAI F Y, YANG W C, et al. Preparation and Characterization of Ferrofluid Stabilized with Biocompatible Chitosan and Dextran Sulfate Hybrid Biopolymer as a Potential Magnetic Resonance Imaging (MRI) T2 Contrast Agent[J]. Marine Drugs, 2012, 10(11): 2403-2414.
[19]  HUANG C C, TSAI C Y, SHEU H S, et al. Enhancing Transversal Relaxation for Magnetite Nanoparticles in MR Imaging Using Gd3+-Chelated Mesoporous Silica Shells[J]. ACS nano, 2011, 5(5): 3905-3916.

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