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盐酸特比萘芬胶囊在比格犬体内的药物动力学及生物利用度研究

DOI: 10.7671/j.issn.1001-411X.2012.04.025, PP. 556-560

Keywords: 盐酸特比萘芬胶囊,比格犬,药物动力学,生物利用度

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Abstract:

为了研究盐酸特比萘芬胶囊在比格犬体内的药物动力学(简称药动学)特征及生物利用度,选用健康比格犬8只,进行单剂量(10mg·kg-1)静脉注射特比萘芬注射液和口服盐酸特比萘芬胶囊,采用双周期随机交叉试验设计,用反相高效液相色谱法测定血药质量浓度,利用Winnolin5.2.1非房室模型计算各药动学参数.结果表明,静注盐酸特比萘芬主要药动学参数为:AUC0-∞=(5.47±1.03)μg·mL-1·h,Vss=(2.55±0.89)L·kg-1,CL=(1.88±0.33)L·h-1·kg-1,t1/2=(3.02±1.70)h;口服盐酸特比萘芬胶囊主要药动学参数为:tmax=(1.09±0.37)h,Cmax=(0.39±0.04)μg·mL-1,AUC0-∞=(0.67±0.18)μg·mL-1·h,Vd/F=(35.17±6.58)L·kg-1,t1/2=(1.69±0.74)h.比格犬口服盐酸特比萘芬胶囊的绝对生物利用度为(12.54±3.43)%.特比萘芬在比格犬体内吸收迅速,消除快,生物利用度低.

References

[1]  NEWLAND J G,ABDEL-RAHMAN S M,Update on terbinafine with a focus on dermatophytoses,Clin Cosmet Investig Dermatol,2009(2).
[2]  金艺鹏,林德贵..盐酸特比萘芬对犬猫皮肤病的疗效观察[J].中国兽医杂志,2003,(06):21-23.doi:10.3969/j.issn.0529-6005.2003.06.007.
[3]  陆桂平,盐酸特比萘芬和复方酮康唑对犬真菌病的临床疗效观察,养犬,2008.
[4]  王庆华,金艺鹏,孙艳争..口服盐酸特比萘芬在猫毛发中的药物浓度分布[J].中国兽医杂志,2011,(07):60-61.doi:10.3969/j.issn.0529-6005.2011.07.028.
[5]  MANCIANTI F,PEDONESE F,MILLANTA F,Efficacy of oral terbinafine in feline dermatophytosis due to microsporum canis,JOURNAL OF FELINE MEDICINE & SURGERY,1999(1).
[6]  DENOU(E)L J,KELLER H P,SCHAUB P,Determination of terbinafine and its desmethyl metabolite in human plasma by high-performance liquid chromatography,Journal of Chromatography.B,Biomedical Applications,1995(2).
[7]  Bechert, Ursula ;Christensen, J. Mark ;Poppenga, Robert ;Le, Hang ;Wyatt, Jeff ;Schmitt, Todd,PHARMACOKINETICS OF ORALLY ADMINISTERED TERBINAFINE IN AFRICAN PENGUINS (SPHENISCUS DEMERSUS) FOR POTENTIAL TREATMENT OF ASPERGILLOSIS,Journal of Zoo and Wildlife Medicine?,2010, 41(2).
[8]  BECHERT U,CHRISTENSEN J M,POPPENGA R,Pharmacokinetics of terbinafine after single oral dose administration in red-tailed hawks (Buteo jamaicensis),JOURNAL OF AVIAN MEDICINE AND SURGERY,2010(2).
[9]  WILLIAMS M M,DAVIS E G,KUKANICH B,Pharmacokinetics of oral terbinafine in horses and Greyhound dogs,Journal of Veterinary Pharmacology and Therapeutics,2011(3).
[10]  HUMBERT H,CABIAC M D,DENOU(E)L J,Pharmacokinetics of terbinafine and of its five main metabolites in plasma and urine,following a single oral dose in healthy subjects,Biopharm & Drug Dispos,1995(8).
[11]  FAERGEMANN J,ZEHENDER H,DENOU(E)L J,Levels of terbinafine in plasma,stratum corneum,dermisepidermis(without stratum corneum),sebum,hair and nails during and after 250 mg terbinafine orally once per day for four weeks,Acta Dermato Venereologica,1993(4).
[12]  Yeganeh,MH ;McLachlan,AJ,Determination of terbinafine in tissues.,Biomedical Chromatography?,2000, 14(4).
[13]  TOUTAIN P L,DEL CASTILLO J R,BOUSQUETM(E)LOU A,The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics,Research in Veterinary Science,2002(2).
[14]  Court,MH ;Hay,Kraus-BL ;Hill,DW ;Kind,AJ ;Greenblatt,DJ,Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences.,Drug Metabolism and Disposition?,1999, 27(11).
[15]  HAY KRAUS B L,GREENBLATT D J,VENKATAKRISHNAN K,Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes:Breed and gender differences,Xenobiotica;The Fate of Foreign Compounds In Biological Systems,2000(6).
[16]  KuKanich B ;Coetzee JF ;Gehring R ;Hubin M,Comparative disposition of pharmacologic markers for cytochrome P-450 mediated metabolism, glomerular filtration rate, and extracellular and total body fluid volume of Greyhound and Beagle dogs,Journal of veterinary pharmacology and therapeutics?,2007, 30(4).
[17]  GUGLER R,LAIN P,AZARNOFF D L,Effect of portacaval shunt on the disposition of drugs with and without first-pass effect,Journal of Pharmacology and Experimental Therapeutics,1975(3).
[18]  GURLEY B J,BARONE G W,YAMASHITA K,Extrahepatic ischemia-reperfusion injury reduces hepatic oxidative drug metabolism as determined by serial antipyrine clearance,Pharmaceutical Research,1997(1).

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