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5-氟尿嘧啶在小鼠结肠癌模型中的药效与毒性评价研究

DOI: 10.7671/j.issn.1001-411X.2012.04.021, PP. 535-538

Keywords: 5-氟尿嘧啶,药效,毒性,结肠癌

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Abstract:

为探讨5-氟尿嘧啶的药效、毒性与给药剂量之间的关系,采用BALB/c小鼠来源的CT26结肠癌细胞株构建小鼠结肠癌模型,分别给予10、20、30和50mg/kg剂量的5-氟尿嘧啶,分析其抗肿瘤效果、对小鼠体质量的影响和死亡率等指标.结果表明,5-氟尿嘧啶的体内抑瘤效果及毒性与剂量密切相关.综合分析评价各指标,认为20~30mg/kg剂量的5-氟尿嘧啶较适合于小鼠结肠癌模型中的药效评价.

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