全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

洛克沙胂在鸡体内的药物动力学和生物利用度研究

DOI: 10.7671/j.issn.1001-411X.2012.03.026, PP. 403-406

Keywords: ,洛克沙胂,药动学,HPLC

Full-Text   Cite this paper   Add to My Lib

Abstract:

50日龄健康岭南三黄肉鸡24只随机分为2组,雌雄各半.分别进行单剂量(10mg·kg-1)静注和内服洛克沙胂的药物动力学(简称药动学)研究.以反相高效液相色谱法测定血浆中洛克沙胂质量浓度,采用WinNonlin5.2药动学软件的非房室模型统计矩原理分析药物质量浓度-时间数据.鸡静注给药后主要药动学参数为:t1/2β=(2.37±0.11)h,Vz=(5.29±0.37)L·kg-1,AUC0-∞=(6.55±0.28)mg·L-1·h,CL=(1.56±0.07)L·h-1·kg-1.内服给药的主要药动学参数为:t1/2β=(3.02±0.08)h,tmax=(1.00±0.07)h,Cmax=(1.09±0.08)mg·L-1,AUC0-∞=(2.30±0.10)mg·L-1·h,MRT=(2.44±0.13)h,F=(35.28±1.0)%.洛克沙胂在鸡体内的药动学特征表现:静注分布较为广泛,消除迅速;内服给药后,吸收较快但不完全,生物利用度较低.

References

[1]  BASU P,GHOSH R N,GROVE L E,Angiogenic potential of 3-nitro-4-hydroxy benzene arsenic acid (roxarsone),Envirn Health Perspecti,2008(4).
[2]  赵兵,猪粪便中洛克沙胂的HPLC检测及消除规律,扬州:扬州学,2007.
[3]  Chen KL ;Chiou PWS,Oral treatment of mule ducks with arsenicals for inducing fatty liver,Poultry Science?,2001, 80(3).
[4]  李银生,曾振灵,陈杖榴,洛克沙胂的作用、毒性及环境行为,上海畜牧兽医通讯,2003(1).
[5]  陈杖榴,杨桂香,孙永学..兽药残留的毒性与生态毒理研究进展[J].华南农业大学学报,2001,(01):88-91.doi:10.3969/j.issn.1001-411X.2001.01.025.
[6]  CHIOU W S,CHEN K L,YU B,Effects of roxarsone on performance,toxicity,tissue accumulation and residue of eggs and excreta in laying hens,Journal of the Science of Food and Agriculture,1997.
[7]  WANG Chia-chi,WU Hsin-ying,JAN Tong-rong,The effect on animal growth and the Impact on the environment by roxarsone,an organic arsenic veterinary drug,Taiwan Veterinary Journal,2010(2).
[8]  Shamil J.Cathum ;Carl E.Brown ;Alison Obenau,Speciation of Arsenic Using Chelation Solvent Extraction and High Performance Liquid Chromatography,Clean - soil, air, water?,2007, 35(1).
[9]  王金荣,张丽英,马永喜,饲料中洛克沙胂的固相萃取-高效液相色谱法检测技术研究,饲料工业,2005(14).
[10]  杨永嘉,王国忠,王雷..高效液相色谱法测定洛克沙胂预混剂含量方法的研究[J].中国兽药杂志,2001,(06):23-26.doi:10.3969/j.issn.1002-1280.2001.06.010.
[11]  曹庆云,颜惜玲,周武艺,高效液相色谱测定鸡肝中洛克沙胂的方法研究,应用化工,2005(10).
[12]  肖亚兵,高健会,曾宇,HPLC-ICP-MS法对动物源性食品中阿散酸、硝苯砷酸与洛克沙胂残留量的同时测定,分析测试学报,2008(11).
[13]  孙永学. 有机胂添加剂的生态毒性及毒性机理研究[D].广州:华南农业大学,2003.
[14]  梁文权,生物药剂学与药物动力学,北京:人民卫生出版社,2007.
[15]  Castagnolo D ;Manetti F ;Radi M,Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones.,Bioorganic and medicinal chemistry?,2009, 17(15).
[16]  Rosal, CG ;Momplaisir, GM ;Heithmar, EM,Roxarsone and transformation products in chicken manure: Determination by capillary electrophoresis-inductively coupled plasma-mass spectrometry,Electrophoresis?,2005, 26(7/8).
[17]  卓家珍. 鸡饲喂洛克沙胂后排泄物中砷形态分析及其降解规律的初步研究[D].广州:华南农业大学,2008.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133