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两面针红外指纹图谱与抗癌活性的谱效研究

Keywords: 两面针,红外指纹图谱,谱效关系,后退消元法

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Abstract:

研究两面针的红外指纹图谱与抗肿瘤活性之间的相互关系.基于不同产地的两面针氯仿提取物的红外指纹图谱特征峰强度及其抗肿瘤活性的效果,采用后退法构建以两面针抑制人胃腺癌7901和人宫颈癌Hela两种肿瘤细胞株的谱效模型.所建立数学模型的预测值与实际测量值的偏差率全部在10%以内,说明两面针红外指纹图谱和两面针抗肿瘤活性之间具有相关性.结果表明,生物碱类成分在两面针抗肿瘤药效活性中发挥了重要的作用.

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