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口蹄疫病毒密码子使用偏性的位点差异(英文)

DOI: 10.3969/j.issn.1000-7091.2013.02.006, PP. 32-37

Keywords: FMDV,血清型,密码子,调控

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Abstract:

分析了FMDV各血清型病毒基因编码起始区与终止区的密码子使用偏性。结果表明,FMDV各血清型中的稀有密码子倾向出现于编码起始区,而终止区附近稀有密码子出现的倾向较弱。这一有趣的现象,可利用"稀有密码子调控假说"来解释为FMDV起始编码区的稀有密码子的使用对其编码区表达具有负调控作用。而终止区附近的这种较弱的倾向性表明,终止区密码子的使用对编码区基因表达的影响可能没有起始区那样强烈。同时说明,"稀有密码子调控假说"不仅适用于细菌,而且也适用于一些病毒基因组。

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