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乙脑病毒Henan-09-03株E蛋白结构与功能生物信息学分析

DOI: 10.7668/hbnxb.2015.05.006, PP. 36-40

Keywords: 乙型脑炎病毒,E蛋白,生物信息学分析

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Abstract:

利用生物信息学软件对Henan-09-03株乙型脑炎病毒(JEV)病毒E蛋白(囊膜蛋白)进行生物信息学分析、预测,为研究JEV的E蛋白基因工程疫苗提供依据。结果表明:E蛋白的分子质量为53kDa,等电点是7.75,消光系数是66515,不稳定系数为27.05,疏水平均值为-0.007,无信号肽,有2个跨膜区、27个蛋白修饰位点、5个二硫键、15个蛋白质结合位点,二级结构为α-β混合型、三级结构以同源四聚体形式存在。

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