刘碧莲, 白俊杰, 劳海华, 等．鳜 hepcidin cDNA 的分子克隆及序列分析[J]．中国水产科学, 2006, 13 ( 6 ) :995 － 1000．[4]安贤惠, 梁建国 , 李卫国 , 等．中国对虾中抗菌短肽的分离纯 化 与 功 能 分 析[J]．中 国 水 产 科 学, 2006, 13(6) : 1012 － 1016．[5]唐启升, 陈松林．海洋生物技术前沿领域研究进展[J]．海洋科学进展, 2004, 22(002) : 123 － 129．[6]杨 绒, 陈松林．水产动物抗菌肽的研究进展[J]．生物技术通报, 2005(002) : 1 － 5．[7]Minami T．The early life history of a flounder Paralichthysolivaceus．[J]．Bulletin of the Japanese Society of Scientific Fisheries, 1982, 48(11 ) : 1581 － 1588．[8]Kumar S, Tamura K, Nei M．MEGA: molecular evolutionary genetics analysis software for microcomputers[J]．Comput Appl Biosci, 1994, 10(2) : 189．[9]Nielsen M, Lundegaard C, Lund O, et al．CPHmodels-3．0-remote homology modeling using structure-guided sequence profiles[J]．Nucleic Acids Research, 2010, 38( Suppl 2) : W576．[10]Delano W L．The PyMOL molecular graphics system．SanCarlos, CA: DeLano Scientific; 2002[Z]．Accessed 6 /25 /2007．Available at http: / /www．pymol．org, 2010．[11]Steiner H, Hultmark D, Engstrm A, et al．Sequence andspecificity of two antibacterial proteins involved in insectimmunity[J]．Nature, 1981 , 292: 246 － 248．[12]李 华, 杨桂文, 温武军．鱼类抗菌肽研究概况[J]．科技信息, 2010(2) : 144．[13]Cole A M, Weis P, Diamond G．Isolation and characterization of pleurocidin, an antimicrobial peptide in theskin secretions of winter flounder[J]．Journal of Biological Chemistry, 1997, 272(18) : 12008 － 12013．[14]Chang C I, Pleguezuelos O, Zhang Y A, et al．Identification of a novel cathelicidin gene in the rainbow trout, Oncorhynchus mykiss[J]．Infection and Immunity, 2005, 73(8) : 5053 － 5064．[15]Shike H, Lauth X, Westerman M E, et al．Bass hepcidinis a novel antimicrobial peptide induced by bacterialchallenge[J]．European Journal of Biochemistry, 2002，269(8) : 2232 － 2237．[16]Park I Y, Park C B, Kim M S, et al．Parasin I, an antimicrobial peptide derived from histone H2A in the catfish，Parasilurus asotus[J]．FEBS Letters, 1998, 437 ( 3 ) :258 － 262．[17]Sussman J L, Lin D, Jiang J, et al．Protein Data Bank( PDB) : database of three-dimensional structural information of biological macromolecules．[J]．Acta Crystallographica-Section A, 1998, 54: 1078 － 1084．[18]Krause A, Sillard R, Kleemeier B, et al．Isolation and biochemical characterization of LEAP-2, a novel bloodpeptide expressed in the liver[J]．Protein Science，2003, 12(1 ) : 143 － 152．[19]Pigeon C, Ilyin G, Courselaud B, et al．A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressedduring iron overload[J]．Journal of Biological Chemistry, 2001 , 276(11 ) : 7811 － 7819．[20]Zhang Y A, Zou J, Chang C I, et al．Discovery and characterization of two types of liver-expressed antimicrobialpeptide 2 ( LEAP-2) genes in rainbow trout[J]．Veterinary Immunology and Immunopathology, 2004, 101 (3 －4) : 259 － 269．[21]Bao B, Peatman E, Xu P, et al．The catfish liver-expressed antimicrobial peptide 2 ( LEAP-2) gene is expressed in a wide range of tissues and developmentallyregulated[J]．Molecular Immunology, 2006, 43 ( 4 ) :367 － 377．
