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核技术  2015 

Fe3O4纳米颗粒-蛋白的相互作用及生物效应

DOI: 10.11889/j.0253-3219.2015.hjs.38.050501, PP. 50501-50501

Keywords: Fe3O4纳米颗粒,蛋白,吸附,选择性,细胞毒性

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Abstract:

研究了在生物医学领域广泛应用的Fe3O4纳米颗粒与多种蛋白(包括白蛋白、纤维蛋白和免疫球蛋白等)的相互作用及其生物学效应,结果发现Fe3O4纳米颗粒与蛋白的相互作用存在蛋白种类选择性,对蛋白的吸附能力由强到弱依次为纤维蛋白>免疫球蛋白>白蛋白。形成的Fe3O4纳米颗粒-蛋白复合物有效地降低了纳米颗粒的细胞毒性。

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