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保护-烷基化-脱保护法制备脂肪仲胺

DOI: 10.11830/ISSN.1000-5013.2010.05.0539, PP. 539-541

Keywords: 仲胺化合物,对甲苯磺酰胺,烷基化,脱保护,DMFDMA

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Abstract:

以对甲苯磺酰胺为原料,经烷基化、镁/甲醇脱去磺酰基保护基制备对称仲胺化合物,合成了9个脂肪仲胺化合物,产率达90%,产品结构经核磁共振氢谱得到确证.将合成的二苄基胺与N,N-二甲基甲酰胺二甲基缩醛进行胺交换反应,制备N,N-二苄基甲酰胺二甲基缩醛(DMFDMA),扩大了该方法的应用范围.

References

[1]  GHOSE A K, VISWANADHAN V N, WENDOLOSKI J J. A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery (Ⅰ):A qualitative and quantitative characterization of know drug database [J]. Journal of Combinatorial Chemistry, 1999(1):55-68.doi:10.1021/cc9800071.
[2]  PORCHEDDU A, GIACOMELLIi G, PIREDDA I. Parallel synthesis of trisubstitued formamidines:A facile and versatile procedure [J]. Journal of Combinatorial Chemistry, 2009(1):126-130.doi:10.1021/cc8001124.
[3]  INSASF S S, WITIAK D T. Facile non-racemizing route for the N-alkylation of hindered secondary amines [J]. Journal of Synthetic Organic Chemistry Japan, 1999(3):435-440.doi:10.1055/s-1999-3399.
[4]  SWAMMURA M, ITO Y. Catalytic asymmetric synthesis by means of secondary interaction between chiral ligands and substrates [J]. Chemical Reviews, 1992(5):857-871.
[5]  HENKEL T, BRUNNE R M, MUELLER H. Statistical investigation into the structural comple mentarity of natural products and synthetic compounds [J]. Angewandte Chemie International Edition in English, 1999(5):643-647.doi:10.1002/(SICI)1521-3773(19990301)38:5< 643::AID-ANIE643> 3.0.CO; 2-G.
[6]  凌青, 李欣, 沈竞康. 仲胺的合成方法新进展 [J]. 合成化学, 2007(3):247-253.doi:10.3969/j.issn.1005-1511.2007.03.001.
[7]  MCVRIDE L J, KIERZEK R, BEAUCAGE S L. Nucleotide chemistry (16):Amidine protecting groups for oligonucleotide synthesis [J]. Journal of the American Chemical Society, 1986(8):2040-2048.doi:10.1021/ja00268a052.
[8]  KER S G, KALMAN T I. Highly water-soluble lipophilic prodrugs of the anti-HIV nucleoside analogue 2’, 3’-dideoxycytidine and its 3’-fluoro derivative [J]. Journal of Medicinal Chemistry, 1992, (11):1996-2001.
[9]  华东理工大学有机化学教研组. 有机合成中的保护基 [M]. 上海:华东理工大学出版社, 2004.604-607.
[10]  NYASSE B, GREHN L, RAGNARSSON U. Mild, efficient cleavage of arenesulfonamides by magnesium reduction [J]. Chemical Communications, 1997.1017-1018.doi:10.1039/a701408b.

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