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天麻素的抗糖尿病作用实验

DOI: 10.11830/ISSN.1000-5013.2013.06.0682

Keywords: 天麻素, 糖尿病, 血糖, 血脂, 抗氧化

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Abstract:

分离、培养人脐静脉内皮细胞(HUVECs),测定在高糖刺激下胞外乳酸脱氢酶(LDH)的活性,并用链脲佐菌素建立糖尿病小鼠模型,分别以不同天麻素质量浓度干预14 d进行试验.研究结果表明:天麻素能降低高糖刺激下HUVECs胞外LDH的活性,减轻高糖对血管内皮细胞造成的损伤;天麻素能显著降低糖尿病小鼠的血糖,降低小鼠血清中甘油三酯、总胆固醇及丙二醛浓度,提高超氧化物歧化酶(SOD)的活性,显示出明显的抗糖尿病作用.

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