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???л?????С??????????????KATP??????????

DOI: 10.11830/ISSN.1000-5013.2008.03.0395

Keywords: ??????, ???, ATP??????????????, ????-??????????

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Abstract:

观察心梗诱导的大鼠肥厚心肌中三磷酸腺苷(ATP)敏感性钾离子通道(KATP)的表达,并探讨其影响因素.将雄性大鼠随机分为5组,分别是假手术组,手术组,普萘洛尔组,氯苄基四氢小檗碱组及内皮素受体拮抗剂组.手术组及药物组的大鼠结扎冠脉左前降支,术后饲养10 d,药物组于术后第6天开始给药,共给药5d,由反转录-多聚酶链式反应(RT-PCR)方法确定KATP通道的mRNA表达.实验结果表明,心梗诱导的大鼠肥大心肌中的KATP通道的mRNA表达明显上调,经药物干预后有不同程度的降低.心梗诱导的大鼠肥厚心肌中的KATP通道的mRNA的表达上调,其表达上调除与β受体有关外,Ca2+离子可能参与对KATP通道表达的影响.

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