心肌梗死相关微RNA的研究进展

微RNA(microRNAs,miRs)是一类非编码RNA,能够调控基因组中大部分基因的表达。心肌梗死(myocardid infarction,MI)常伴随基因表达谱的改变和相关信号通路的失调。miRs在MI中扮演重要角色,其对心肌细胞的存活及缺血后血管生成有着多方面的调控作用。MI后miRs表达升高或下降可能参与心脏整体功能的调节。本文总结了MI相关miRs的最新进展,并讨论了miRs应用于MI治疗中的前景和局限性。
MicroRNAs (miRs) are noncoding RNAs that control a large fraction of the genome. Myocardial infarction (MI) is characterized by strongly altered gene expression, deregulation of underlying signaling pathways and crucial participation of several miRs.miRs plays an important role in MI, and have multiple effects on the survival of cardiomyocytes and post ischemic angiogenesis. After MI miRs induction or repression might regulate overall cardiac function. In this review, we summarize the current knowledge about several miRs after MI and discuss briefly the application and limitations of miRs in treating MI.