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同位素  2010 

炎症显像剂的临床应用及研究进展

, PP. 186-192

Keywords: 炎症,显像剂,临床应用,研究进展

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Abstract:

目前,临床常用炎症显像剂有67Ga-枸椽酸盐、18F-FDG,放射性核素标记的非特异性人免疫球蛋白、白细胞、抗粒细胞单克隆抗体以及环丙沙星。本文对它们的显像原理、临床应用概况以及各自的优缺点进行了简述;并详细介绍了在研的炎症特异性显像剂,如放射性核素标记的细胞因子及其拮抗剂,以及针对病原微生物的感染特异性显像剂,如放射性核素标记的抗菌药、噬菌体、甲壳酶与甲壳结合蛋白、抗菌肽、核苷及其类似物,在炎症/感染灶内的定位机制和它们的研究现状。

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