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同位素  2010 

单管法11C-CH3I的合成条件优化及胆碱生产与临床应用

, PP. 166-169

Keywords: 11C-CH3I,合成,胆碱,条件优化

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Abstract:

通过对合成11C-CH3I所用试剂的用量、反应的载气流量、压力和反应温度、蒸发时间等条件进行优化,进而用柱色层法合成了11C-胆碱。在反应条件为LiAlH4和57%HI的用量分别为0.3mL和0.5mL,反应的最佳载气流量和压力分别为27mL/min、0.28kPa,反应温度为180℃,蒸发时间为12min下,11C-CH3I的校正后标记产率为62.2%±3.4%,放化纯度>95%。临床脑胶质瘤和前列腺瘤疑似患者各1例在18F-FDG显像24h后分别接受11C-胆碱检查,并与18F-FDG显像结果对照。显像结果表明,18F-FDG检查示低代谢区11C-胆碱均呈高代谢,联合用药可以更准确地区分病变的性质。

References

[1]  Shinoura N, Nishijima M, Hara T, et al. Brain tumors: detection with 11C-choline PET[J]. Radiology, 1997, 202: 497-503.
[2]  de Winter F, Van de Wiele C, Dumont F, et al. Biodistribution and dosimetry of 99m-Tc-ciprofloxacin, a promising agents for diagnosis of bacterial infection[J]. Eur J Nucl Med, 2001, 28: 570-574.
[3]  Hara T, Kosaka N, Kishi H. PET imaging of prostate cancer using 11C-choline[J]. J Nucl Med, 1998, 39: 990-995.
[4]  Britton KE, Vinjamuri S, Hall AV, et al. Imaging bacterial infection with (99m)Tc- ciprofloxacin (Infecton) [J]. J Clin Pathol, 2002, 55: 817-823.
[5]  Dumarey N, Blocklet D, Appelboom T, et al. Infecton is not specific for bacterial osteoarticular infective pathology[J]. Eur J Nucl Med, 2002, 29: 530-535.
[6]  Sarda L, Cremieux AC, Lebellec Y, et al. Inability of 99mTc-ciprofloxacin scintigraphy to discriminate between septic and sterile osteoarticular disease[J]. J Nucl Med, 2003, 44: 920-926.
[7]  Siaens RH, Rennen HJ, Boerman OC, et al. Synthesis and evaluation of 99mTc-enrofloxacin, 99mTc-ciprofloxacin[J]. J Nucl Med, 2004, 45: 2 088-2 094.
[8]  Zhang H, Tian M, Oriuchi N, et al. 11C2-choline PET for the detection of bone and soft tissue tumors in comparison with FDG PET[J]. Nucl Med Commun, 2003, 24: 273-279.
[9]  刘续磊,陶荣杰. 应用11C-胆碱PET/CT鉴别恶性胶质瘤复发与坏死的研究进展[J].现代肿瘤学,2007,15(11):1 692-1 694.
[10]  Zijlstra S, Gunawan J, Freytag C, et al. Synthesis and evaluation of fluorine18 labeled compounds for imaging of bacterial infections with PET[J]. Appl Radiat Isot, 2006, 64: 802-807.
[11]  Langer O, Brunner M, Zeitlinger M, et al. In vitro and in vivo evaluation of [(18)F]-ciprofloxacin for imaging of bacterial infections with PET[J]. Eur J Nucl Med Mol Imaging, 2005, 32: 143-150.
[12]  Procaccini E, Chianelli M, Pantano P, et al. Imaging of autoimmune disease[J]. Q J Nucl Med, 1999, 43: 100-112.
[13]  Signore A, Chianelli M, Annovazi A, et al. 123I-interleukin-2 scintigraphy for in vivo assessment of interstitial mononuclear cell infiltration in Crohn’s disease[J]. J Nucl Med, 2000, 41: 242-249.
[14]  Rennen HJ, Bleeker-rovers CP, van Eerd JE, et al. 99mTc-labeled interleukin-8 for scintigraphic detection of pulmonary infections[J]. Chest, 2004, 126: 1 954-1 961.
[15]  Bleeker-rovers CP, Rennen HJ, Boerman OC, et al. 99mTc-labeled interleukin8 for scintigraphic detection of infection and inflammation: first clinical evaluation[J]. J Nucl Med, 2007, 48: 337-343.
[16]  van Eerd JE, Boerman OC, Corstens FH, et al. Radiolabeled chemotactic cytokines: new agents for scintigraphic imaging of infection and inflammation[J]. Q J Nucl Med, 2003, 47: 246-255.
[17]  van Eerd JE, Broekema M, Harris TD, et al. Scintigraphic detection of pulmonary aspergillosis in rabbits with a radiolabeled leukotriene b4 antagonist[J]. J Nucl Med, 2004, 45: 1 747-1 753.
[18]  Diksic Y, Yamamoto L, Feindel W. Synthesis of 11C-labeled choline[J]. J Labelled Comp Radiopharm, 1984, 14: 9-15.
[19]  van Eerd JE, Broekema M, Harris TD, et al. Imaging of infection and inflammation with an improved 99mTc-labeled LTB4 antagonist[J]. J Nucl Med, 2005, 46: 1 546-1 551.
[20]  Pascali C, Bogni A, Iwata R, et al. 11C-methylation on a C18 Sep-Pakcartridge: a convenient way to produce N-methyl-11C-choline[J]. J Labelled Comp Radiopharm, 2000, 43: 195203.
[21]  张锦明,田嘉禾,杨志,等.自动化制备11C-胆碱及临床应用[J].中华核医学杂志,2004,24(1):46-48.

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