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同位素  2010 

4-甲基咪唑双膦酸的合成及其99Tcm标记

, PP. 225-229

Keywords: 99Tcm,标记,双膦酸,M4IDP

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Abstract:

以4-甲基咪唑为原料,通过N-烷基化、酯水解和磷酸酰化三步反应,合成1-羟基-2-(4-甲基-1H-咪唑基)-乙烷-1,1-双膦酸(M4IDP),目标产物和重要中间体通过IR、MS及1HNMR进行结构鉴定;采用Na99TcmO4标记M4IDP,得到标记物99Tcm-M4IDP,并测定其体外稳定性。结果显示,标记物的最佳标记条件为反应时间30min,反应体系pH为6,SnCl2·2H2O用量100μg,配体用量5mg。在此条件下,标记率>95%,室温下存放6h,放化纯度>95%,说明99Tcm-M4IDP具有较好的体外稳定性。

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