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同位素  2011 

Octreotide的131I标记及Graves眼病炎症细胞的体外摄取

, PP. 94-97

Keywords: 131I,octreotide,标记,Graves眼病,炎症细胞

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Abstract:

将octreotide中的苯丙氨酸用酪氨酸替换合成[Tyr3]octreotide,对其进行了131I标记。考察了氯胺T标记法中氯胺T和[Tyr3]octreotide的用量对标记率的影响,观察了Graves眼病相关炎症细胞对131I-[Tyr3]octrotide的体外摄取情况。结果表明,对octreotide进行结构修饰后得到的[Tyr3]octreotide可以用于131I标记;氯胺T法对[Tyr3]octreotide进行131I标记时,氯胺T和[Tyr3]octreotide的最佳用量分别为1.6和1.4μg,最高标记率为85%;T淋巴细胞、活化的成纤维细胞及血管内皮细胞均能够摄取131I-[Tyr3]octreotide,而脂肪细胞的摄取则明显较少。以上结果表明,131I-[Tyr3]octreotide能够被Graves眼病发病过程中的炎症细胞摄取,具有用于Graves眼病发病过程中炎症反应程度评估的应用潜力。但由于摄取量还很小,需要进一步深入研究。

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