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同位素  2011 

液质联用法测定常用18F药物中Kryptofix2.2.2的含量

, PP. 188-192

Keywords: 液质联用,18F药物,K2.2.2含量

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Abstract:

利用液质联用法定量分析了常用18F药物中Kryptofix2.2.2(K2.2.2)的含量。选择母离子为(M+H)+377.4,使用合适的多反应监测离子对方法(MRM),建立了定量范围为20~500μg/L的K2.2.2标准曲线,线性相关系数为0.9999,系统回收率和精密度均符合要求。利用此方法测量常规制备的18F-FDG中K2.2.2的含量低于20μg/L,5批次18F-FLT中K2.2.2的含量为0.286~16.9mg/L。以上结果表明,液质联用法是测定K2.2.2含量最灵敏的方法。

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