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同位素  2011 

99Tcm-MAVGG-Glu的肿瘤定位性能

, PP. 172-176

Keywords: 99Tcm,MAVGG-Glu,肿瘤,定位性能

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Abstract:

用99Tcm标记了β-N-巯基乙酰基-缬氨酰-甘氨酰-甘氨酰-葡萄糖(MAVGG-Glu),对标记物在荷S180肉瘤在小鼠体内的生物分布与显像进行了研究,并与18F-FDG的生物分布进行对比。结果显示,99Tcm对MAVGG-Glu的标记率大于90%。注射后3h和5h,99Tcm-MAVGG-Glu在肿瘤中的摄取率分别为1.46±0.41和1.28±0.24%ID/g;注射后5h,肿瘤与除肝、肾外的正常组织的放射性摄取比(T/NT)均高于1.8,其中肿瘤与血液、肿瘤与肌肉和肿瘤与脑的T/NT分别为4.41、4.00和8.53。静脉注射3h后,肿瘤即可显影,随时间延长,肿瘤与正常组织的对比度略有增高。以上结果提示,99Tcm-MAVGG-Glu有可能应用于肿瘤显像。与18F-FDG相比,99Tcm-MAVGG-Glu在肿瘤中的摄取率以及肿瘤与大多数组织的T/NT均较低,但肿瘤与肌肉、心脏、脾和脑的T/NT高于18F-FDG,尤其是肿瘤与脑的T/NT显著高于18F-FDG,提示其在脑瘤以及大脑附近的肿瘤显像中较18F-FDG更具优势。

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