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同位素  2015 

金属核素在放射免疫治疗药物中的应用

DOI: 10.7538/tws.2015.28.02.0113, PP. 113-120

Keywords: 放射性金属核素,单克隆抗体,放射性免疫治疗

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Abstract:

恶性肿瘤及其转移瘤的放射免疫靶向治疗越来越受到重视,已经成为治疗核医学的重要发展方向之一。放射免疫治疗药物对肿瘤细胞具有靶向选择性杀伤作用,可减少对正常非靶组织的损伤。鉴于131I标记单抗易在体内脱碘,近年来,金属核素在单抗药物方面的应用已成为放射免疫治疗药物的研究重点。本文分别从金属核素、双功能螯合剂和放射免疫靶向治疗药物三个方面对金属核素标记放射免疫治疗药物的发展现状进行了综述。

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