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同位素  2011 

U(Ⅵ)在人体组织液中的形态模拟

, PP. 52-57

Keywords: U(Ⅵ),组织液,形态,模拟

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Abstract:

铀的毒性与其体内形态密切相关,研究铀在人体组织液的形态有助于了解铀的人体毒理。本工作采用热力学平衡模拟方法研究U(Ⅵ)在人体组织液中的形态。建立了含多种金属离子和小分子配体组成的多相组织液热力学平衡模型,模拟研究了H2OCO32--PO43-体系中UO22+的形态分布、组织液中UO22+的形态分布及总CO32-次氮三酯酸(NTA)浓度对组织液中UO22+形态分布的影响。结果表明,在H2O-CO32--PO43-体系中,当UO22+总浓度为1.5μmol/L、pH>7.0时,UO22+主要以[UO2(CO3)3]4-和[UO2(CO3)2]2-存在,pH2HPO4和UO2(H2PO4)2存在;当UO22+浓度为0.15mmol/L、pH>7.0时,UO22+仍以[UO2(CO3)3]4-和[UO2(CO3)2]2-为主,pH3~6时,主要以固相(UO2)3(PO4)2出现。在组织液模型中,当UO22+总浓度为1.5μmol/L、pH>7.0时,UO22+主要以[UO2(CO3)3]4-、[UO2(CO3)2]2-和[UO2Cit2]4-存在,pH2Cit2]4-存在;当UO22+浓度为0.15mmol/L、pH>7.0时,UO22+仍以[UO2(CO3)3]4-、[UO2(CO3)2]2-和[UO2(CO3)3]4-存在,pH3~6时,以固相(UO2)3(PO4)2为主。当UO22+浓度为1.5μmol/L或0.15mmol/L时,提高CO32-浓度能改变UO22+在组织液中的形态分布[UO2(CO3)3]4-含量升高,[UO2(CO3)2]2-和[UO2Cit2]4-含量降低。NTA的加入改变了组织液中UO22+的形态分布,但并没产生UO22+的NTA螯合物形态。当UO22+浓度为1.5μmol/L时,提高NTA浓度可使UO22+主要以[UO2Cit2]4-存在;当UO22+浓度为0.15mmol/L时,UO22+主要以[UO2(CO3)2]4-形式存在。

References

[1]  Baston GMN, Brownsword M, Cross JE, et al. The solubility of uranium in cementitious near-field chemical conditions [M]. Oxford: United Kingdom Atomic Energy Authority, 1993.
[2]  Lemire RJ, Tremaine PR. Uranium and plutonium equilibriums in aqueous solutions to 200 ℃[J]. J Chem Eng Data, 1980, 23: 361-370. 
[3]  Sanding A, Bruno J. The solubility of (UO2)3PO4)●4H2O(s) and the formation of U(Ⅵ) phosphate complexes: their influence in uranium speciation in natural waters[J]. Geochim Cosmo Acta, 1992, 56: 4 135-4 145.
[4]  Koban A,Bernhard G. Uranium(VI) complexes with phospholipid model compounds: a laser spectroscopic study[J]. J Inorg Biochem, 2007, 101: 750-757.
[5]  Fortin C, Dutel L, Garnier LJ. Uranium complexation and uptake by a green alga in relation to chemical speciation: the importance of the free uranyl ion[J]. Environ Toxicol Chem, 2004, 23: 974-981.
[6]  Limson Zamora M, Zielinski JM, Meyerhof D, et al. Uranium gastrointestinal absorption: the f1 factor in humans[J]. Radiat Prot Dosim, 2003, 105: 55-60.
[7]  Williams DR. Chemical speciation contributing to research knowledge and everyday life[J]. Coord Chem Rev, 1999, 185-186: 177-188.
[8]  Scott LM. Environmental monitoring and personnel protection in uranium processing[M]// Hodge HC, Stannard JN, Hursh JB, Eds. Handbook of experimental pharmacologys uranium, plutonium, transplutonic elements. NY: Springer Verlag, 1973: 271.
[9]  Durbin PW,Kullgren B, Ebbe SN,et al. Chelating agents for uranium(VI): 2. Efficacy and toxicity of tetradentate catecholate and hydroxypyridinonate ligands in mice[J]. Health Phys, 2000,78 (5): 511-521.
[10]  Domingo JL,Ortega A,Llobet JM, et al. Effectiveness of chelation therapy with time after acute uranium intoxication. Fundam[J]. Appl Toxicol, 1990, 14: 88-95.
[11]  Mark Sutton,Stephen RB. Beryllium chemical speciation in elemental human biological fluids[J]. Chem Res Toxicol, 2003, 16: 1 145-1 154.
[12]  Peter May, Linder PW, David RW.Computer simulation of metalion equilibria in biofluids:Models for the low-molecular-weight complex distribution of calcium(Ⅱ),magnesium(Ⅱ),manganese(Ⅱ),iron(Ⅲ),copper(Ⅱ),zinc(Ⅱ),and lead(Ⅱ)ions in human blpod plasma[J]. J Chem Soc Dalton Trans, 1977, (6): 588-595.
[13]  Lu Xing,Wang Yue,Zhang Haiyun,et al. Computer Simulation for Efect of Tb3+ on Ca2+ Speciation in Human Piasma[J]. J Rare Earth, 2002,20: 238-240.
[14]  Zhang HaiYuan,Wang JinPing,LU Xing,et al. Computer simulation for effect of Pr(Ⅲ) on Zn(Ⅱ) speciation in human interstitial fluid[J]. 中国科学院研究生院学报, 2002, 19: 388-393.
[15]  徐晓莉,马涧泉. 医学生物化学[M]. 北京: 人民卫生出版社,1998.
[16]  蒋树斌,罗顺忠,邴文增,等. SmNTMP水溶液热力学平衡模拟[J]. 化学研究与应用, 2004, 16(4): 336-339.
[17]  Wanner H, Forest I. Chemical thermodynamics of uranium[M]. North-Holland, Amsterdam:Elsevier, 1992.
[18]  Denison FH, Jacqueline GL. The effects of database parameter uncertainty on uranium(Ⅵ) equilibrium calculations[J]. Geochim Cosmo Acta, 2005, 69: 2 183-2 191.
[19]  Stefano CD, Gianguzza A, Leggio T, et al. Dependence on ionic strength of the hydrolysis constants for dioxouranium(Ⅵ) in NaCl(aq) and NaNO3(aq), at pH < 6 and t = 25 ℃[J]. J Chem Eng Data, 2002, 47: 533-538.
[20]  Palmer DA, Trung CN. Aqueous uranyl complexes: 3. potentiometric measurements of the hydrolysis of uranyl(Ⅵ) ion at 25 ℃[J]. J Solution Chem, 1995, 24: 1 281-1 291.

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